國家衛生研究院 NHRI:Item 3990099045/9319
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    题名: Microscopic haematuria and clinical outcomes in patients with Stage 3-5 nondiabetic chronic kidney disease
    作者: Lin, HYH;Yen, CY;Lim, LM;Hwang, DY;Tsai, JC;Hwang, SJ;Hung, CC;Chen, HC
    贡献者: Division of Geriatric Research
    摘要: Microscopic haematuria is proposed as a prognostic factor for renal outcomes in patients with glomerulonephritis. However, the role of haematuria in patients with advanced chronic kidney disease (CKD) or heavy proteinuria has not been investigated. We divided 1799 patients with stage 3-5 nondiabetic CKD into 3 groups according to the results from 3 urinalyses: no haematuria (0-2 red blood cells [RBCs]/hpf >/=2 times), mild haematuria (2-5 RBCs/hpf >/=2 times) and moderate haematuria (>/=5-10 RBCs/hpf >/=2 times). The estimated glomerular filtration rate was 25.4 mL/min/1.73 m(2), with a urine protein-to-creatinine ratio (UPCR) of 881 mg/g. The hazard ratios (HRs) of mild and moderate haematuria for end-stage renal disease (ESRD) were 1.28 (95% confidence interval [CI]: 1.05-1.56, P = 0.024) and 1.34 (95% CI: 1.03-1.74, P = 0.030), respectively. The HR of moderate haematuria for mortality was 1.56 (95% CI: 1.11-2.20, P = 0.011). According to subgroup analysis, the HR of moderate haematuria for ESRD in patients with a UPCR of <500 mg/g was more prominent than that in patients with a UPCR of >/=500 mg/g. Microscopic haematuria in patients with stage 3-5 nondiabetic CKD is associated with increased risks of ESRD and mortality.
    日期: 2015-10
    關聯: Scientific Reports. 2015 Oct;5:Article number 15242.
    Link to: http://dx.doi.org/10.1038/srep15242
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000362868900002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84944225429
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