國家衛生研究院 NHRI:Item 3990099045/9365

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Title:	Increased galectin-3 was closely associated with arterial wave reflections and provided incremental prognostic value upon natriuretic peptide in patients with acute heart failure
Authors:	Cheng, HM;Sung, SH;Yu, WC;Chuang, SY;Chen, CH
Contributors:	Division of Health Services and Preventive Medicine
Abstract:	Background: Galectin-3, a marker of cardiac ﬁbrosis, is an emergent prognostic biomarker in heart failure. However, its associations with hemodynamic parameters and whether it has an incremental prognostic value upon natriuretic peptide in acute heart failure syndrome (AHFS) remained unclear. Methods and results: Galectin-3 and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were measured in 125 participants hospitalized due to AHFS (mean age 70.4 years; 82% women). We assessed determinants of increased Galectin-3 using logistic regression model and the relation of Galectin-3 to adverse cardiovascular (CV) outcomes by proportional hazards regression. Measures of hemodynamic parameters by tonometry and thoracic ﬂuid content (TFC) by impedance cardiography were obtained within 24 hours of admission. During a median follow-up of 601 days, 66 adverse events developed. In multivariate model, increased Galectin-3 (>25.9ng/ml) was signiﬁcantly associated with estimated creatinine clearance with odd ratio (OR) 0.194 (95% conﬁdence interval [CI] 0.101–0.373; p<0.0001) and backward arterial wave reﬂections (Pb; OR 2.11; 95% CI 1.20–3.71; p=0.0096). Elevated Galectin-3 was associated with risk for adverse outcomes after adjustment for clinical variables and NT-proBNP (HR: 3.49; 95% CI: 1.04 to 11.72; p=0.04). Moreover, the addition of Galectin-3 resulted in signiﬁcant net incremental improvement in risk assessment (net reclassiﬁcation index 0.514, 95% CI 0.078–0.949, p=0.021). Conclusion: The association of Galectin-3 with Pb linked increased Galectin-3 with small arteriolar pathology in AHFS. The independent and incremental prognostic value of Galectin-3 upon NT-proBNP lend support to the clinical application of Galectin-3 in the management of AHFS.
Date:	2015-08
Relation:	European Heart Journal. 2015 Aug;36(Suppl.1):840.
Link to:	http://dx.doi.org/10.1093/eurheartj/ehv400
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0195-668X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000361205105587
Appears in Collections:	[Shao-Yuan Chuang] Conference Papers/Meeting Abstract

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