國家衛生研究院 NHRI:Item 3990099045/9421
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    题名: Anti-alpha-enolase is a prognostic marker in postoperative lung cancer patients
    其它题名: Anti-α-enolase is a prognostic marker in postoperative lung cancer patients
    作者: Hsiao, KC;Shih, NY;Chu, PY;Hung, YM;Liao, JY;Chou, SW;Yang, YY;Chang, GC;Liu, KJ
    贡献者: National Institute of Cancer Research
    摘要: Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of anti-ENO1 Ab were assessed in 85 non-small cell lung carcinoma patients before and after surgery, and were correlated with clinical outcome. After surgery, patients with a higher increase of anti-ENO1 Ab had a lower hazard ratio and a better progression-free survival. Using animal models, we demonstrated that tumor cells reduce the circulating levels of anti-ENO1 Ab through physical absorption and neutralization of anti-ENO1 Ab with surface-expressed and secreted ENO1, respectively. Mice transplanted with ENO1-overexpressing tumors generated ENO1-specific regulatory T cells to suppress the production of anti-ENO1 Ab. Our results suggest that the increase of anti-ENO1 Ab may reflect anti-tumor immune responses and serve as a prognostic marker in postoperative lung cancer patients.
    日期: 2015-09-26
    關聯: Oncotarget. 2015 Sep 26;6(33):35073-35086.
    Link to: http://dx.doi.org/10.18632/oncotarget.5316
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000366107200090
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84946568787
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