國家衛生研究院 NHRI:Item 3990099045/9444

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Title:	Self-concentrating buoyant glass microbubbles for high sensitivity immunoassays
Authors:	Juang, DS;Hsu, CH
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Here, we report the novel application of a material with self-concentrating properties for enhancing the sensitivity of immunoassays. Termed as glass microbubbles, they are antibody functionalized buoyant hollow glass microspheres that simultaneously float and concentrate into a dense monolayer when dispensed in a liquid droplet. This self-concentrating charactaristic of the microbubbles allow for autonomous signal localization, which translates to a higher sensitivity compared to other microparticle-based immunoassays. We then demonstrated a "microbubble array" platform consisting of the glass microbubbles floating in a microfluidic liquid hemisphere array for performing multiplex immunoassays.
Date:	2016-01-26
Relation:	Lab on a Chip. 2016 Jan 26;16(3):459-464.
Link to:	http://dx.doi.org/10.1039/c5lc01005e
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1473-0197&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000368858700005
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84956722570
Appears in Collections:	[Chia-Hsien Hsu] Periodical Articles

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