國家衛生研究院 NHRI:Item 3990099045/9445
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9445


    Title: Biphasic release of gentamicin from chitosan/fucoidan nanoparticles for pulmonary delivery
    Authors: Huang, YC;Li, RY;Chen, JY;Chen, JK
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: Gentamicin (GM), one of the most commonly used aminoglycoside antibiotics, has been used for treating pneumonia; however, the applicability of GM is limited by its bioavailability and toxic side effects. This study used chitosan (CS)/fucoidan (F) nanoparticles (NPs) to develop a nanoformulation for pulmonary delivery of GM, presenting a biphasic release feature. The NPs exhibited a zero-order release of GM for the first 10 h, followed by a sustained release of up to 72 h, attaining a value of 99%. The GM-loaded CS/F NPs provide multiple antimicrobial capabilities against Klebsiella pneumoniae, including the CS and biphasic release of GM. Compared with the intravenous administration of free GM (0.5 mg/kg), the intratracheal administration of GM-loaded CS/F NP (0.27 mg/kg) presented a superior area under the concentration–time curve/minimum inhibitory concentration ratio, indicating the simultaneous improvement of antimicrobial efficacy and elimination of systemic toxicity. These results suggested that CS/F NPs are potential carriers in pulmonary delivery of GM for pneumonia treatment.
    Date: 2016-03-15
    Relation: Carbohydrate Polymers. 2016 Mar 15;138:114-122.
    Link to: http://dx.doi.org/10.1016/j.carbpol.2015.11.072
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0144-8617&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000368096400014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84962010003
    Appears in Collections:[Jen-Kun Chen] Periodical Articles

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