國家衛生研究院 NHRI:Item 3990099045/9510
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    题名: Prolonged postprocedural outbreak of Mycobacterium massiliense infections associated with ultrasound transmission gel
    作者: Cheng, A;Sheng, WH;Huang, YC;Sun, HY;Tsai, YT;Chen, ML;Liu, YC;Chuang, YC;Huang, SC;Chang, CI;Chang, LY;Huang, WC;Hsueh, PR;Hung, CC;Chen, YC;Chang, SC
    贡献者: Division of Infectious Diseases
    摘要: Background postprocedural infections by Mycobacterium abscessus complex are increasing worldwide and the source and route of transmission are infrequently identified. Here the extension of a previous clustering of paediatric patients with surgical site infections due to a single strain of the subspecies M. massiliense is reported. Methods Investigation conducted at a 2200-bed teaching hospital in Taiwan including microbial surveillance of the environment (water, air, equipment and supplies) and a case-control study. We performed molecular identification and typing of the isolates by a trilocus sequencing scheme, confirmed by multilocus sequencing typing (MLST) and pulsed-field gel electrophoresis (PFGE). Results We investigated 40 patients who developed post-procedure, soft tissue or bloodstream infections by M. massiliense (TPE101), during a 3-year period. 38 patients were identified at hospital A, one newborn and her mother were identified at hospital B (185 kilometers from hospital A). A case-control study identified the association of invasive procedures (adjusted odds ratio [aOR] 9.13) and ultrasonography (aOR 2.97) (both p<0.05) with acquiring the outbreak strain. Isolates from the cases and unopened bottles of ultrasound transmission gel were all ST48 and indistinguishable or closely related by PFGE. After replacement of contaminated gel, no new cases have been detected in the 18 months of follow-up. Conclusions This investigation identified the use of contaminated gel as the common source causing an outbreak on a larger scale than had been recognised. Our findings halted production by the manufacturer and prompted revision of hospital guidelines.
    日期: 2016-04
    關聯: Clinical Microbiology and Infection. 2016 Apr;22(4):382.e1-382.e11.
    Link to: http://dx.doi.org/10.1016/j.cmi.2015.11.021
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1198-743X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000375399900019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84963725764
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