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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/9521
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| Title: | Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women |
| Authors: | Wang, Z;Seow, WJ;Shiraishi, K;Hsiung, CA;Matsuo, K;Liu, J;Chen, K;Yamji, T;Yang, Y;Chang, IS;Wu, C;Hong, YC;Burdett, L;Wyatt, K;Chung, CC;Li, SA;Yeager, M;Hutchinson, A;Hu, W;Caporaso, N;Landi, MT;Chatterjee, N;Song, M;Fraumeni, JF, Jr.;Kohno, T;Yokota, J;Kunitoh, H;Ashikawa, K;Momozawa, Y;Daigo, Y;Mitsudomi, T;Yatabe, Y;Hida, T;Hu, Z;Dai, J;Ma, H;Jin, G;Song, B;Wang, Z;Cheng, S;Yin, Z;Li, X;Ren, Y;Guan, P;Chang, J;Tan, W;Chen, CJ;Chang, GC;Tsai, YH;Su, WC;Chen, KY;Huang, MS;Chen, YM;Zheng, H;Li, H;Cui, P;Guo, H;Xu, P;Liu, L;Iwasaki, M;Shimazu, T;Tsugane, S;Zhu, J;Jiang, G;Fei, K;Park, JY;Kim, YH;Sung, JS;Park, KH;Kim, YT;Jung, YJ;Kang, CH;Park, IK;Kim, HN;Jeon, HS;Choi, JE;Choi, YY;Kim, JH;Oh, IJ;Kim, YC;Sung, SW;Kim, JS;Yoon, HI;Kweon, SS;Shin, MH;Seow, A;Chen, Y;Lim, WY;Liu, J;Wong, MP;Lee, VH;Bassig, BA;Tucker, M;Berndt, SI;Chow, WH;Ji, BT;Wang, J;Xu, J;Sihoe, AD;Ho, JC, .;et al. |
| Contributors: | Division of Biostatistics and Bioinformatics;National Institute of Cancer Research;Division of Clinical Trial Statistics |
| Abstract: | Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 x 10-13), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 x 10-10) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 x 10-9). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings. |
| Date: | 2016-01-04 |
| Relation: | Human Molecular Genetics. 2016 Jan 4;25(3):620-629. |
| Link to: | http://dx.doi.org/10.1093/hmg/ddv494 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-6906&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000372149500017 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84960858474 |
| Appears in Collections: | [張憶壽] 期刊論文
[熊昭] 期刊論文
[蕭金福] 期刊論文
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| PUB26732429.pdf | | 377Kb | Adobe PDF | 534 | View/Open |
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