國家衛生研究院 NHRI:Item 3990099045/9538
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9538


    Title: Investigating hyperoxic effects in the rat brain using quantitative susceptibility mapping based on MRI phase
    Authors: Hsieh, MC;Kuo, LW;Huang, YA;Chen, JH
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: Purpose: To test whether susceptibility imaging can detect microvenous oxygen saturation changes, induced by hyperoxia, in the rat brain. Methods: A three-dimensional gradient-echo with a flow compensation sequence was used to acquire T2*-weighted images of rat brains during hyperoxia and normoxia. Quantitative susceptibility mapping (QSM) and QSM-based microvenous oxygenation venography were computed from gradient-echo (GRE) phase images and compared between the two conditions. Pulse oxygen saturation (SpO2) in the cortex was examined and compared with venous oxygen saturation (SvO2) estimated by QSM. Oxygen saturation change calculated by a conventional Δ R2* map was also compared with the ΔSvO2 estimated by QSM. Results: Susceptibilities of five venous and tissue regions were quantified separately by QSM. Venous susceptibility was reduced by nearly 10%, with an SvO2 shift of 10% during hyperoxia. A hyperoxic effect, confirmed by SpO2 measurement, resulted in an SvO2 increase in the cortex. The ΔSvO2 between hyperoxia and normoxia was consistent with what was estimated by the Δ R2* map in five regions. Conclusion: These findings suggest that a quantitative susceptibility map is a promising technique for SvO2 measurement. This method may be useful for quantitatively investigating oxygenation-dependent functional MRI studies.
    Date: 2017-02
    Relation: Magnetic Resonance in Medicine. 2017 Feb;77(2):592-602.
    Link to: http://dx.doi.org/10.1002/mrm.26139
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0740-3194&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000394544700016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84956926696
    Appears in Collections:[Li-Wei Kuo] Periodical Articles

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