國家衛生研究院 NHRI:Item 3990099045/9555

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Title:	Characterization of the near full-length genome of a novel HIV-1 CRF01_AE/CRF07_BC recombinant in an injection drug user from Southern Taiwan
Authors:	Lee, NY;Wang, JC;Lin, YC;Wu, CJ;Wang, SW;Li, CW;Li, MC;Tseng, FC;Ko, WC
Contributors:	Division of Infectious Diseases
Abstract:	HIV-1 CRF07_BC became prevalent in Taiwan after the epidemic among injection drug users (IDUs). We describe a unique recombinant form (URF) consisting of CRF01_AE and CRF07_BC (named URF_0107-H8) genes detected from an IDU. The 8.8kb near full-length genome of URF_0107-H8 had a CRF01_AE backbone with two CRF07_BC fragments in the reverse transcriptase and integrase region (RT-Int; HXB2 nucleotide (nt) positions 2942-4709) and within the envelop (nt 8467-8722) gene. Phylogenetic analyses revealed that its 1.8kb RT-Int sequence clustered with those of CRF07_BC strains from Taiwan, while sequences of CRF01_AE portions were more similar to those of Central Africa origin than contemporaneous CRF01_AE isolates in Taiwan or prevalent in East or Southeast Asia. Recombination breakpoints and phylogenetic relationships of URF_0107-H8 were different from those of CRF01_AE/CRF07_BC URFs previously reported from China. This highlighted the importance of continual monitoring of genetic evolution of HIV strains and the emergence of new recombinants.
Date:	2016-06
Relation:	AIDS Research and Human Retroviruses. 2016 Jun;32(6):588-594.
Link to:	http://dx.doi.org/10.1089/aid.2015.0246
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0889-2229&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000376983300011
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84971440562
Appears in Collections:	[Chi-Jung Wu] Periodical Articles [Fan-Chen Tseng] Periodical Articles

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