國家衛生研究院 NHRI:Item 3990099045/9558
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9558


    Title: The rapid suicide protection of mood stabilizers on patients with bipolar disorder: A nationwide observational cohort study in Taiwan
    Authors: Tsai, CJ;Cheng, C;Chou, PH;Lin, CH;McInnis, MG;Chang, CL;Lan, TH
    Contributors: Center for Neuropsychiatric Research
    Abstract: BACKGROUND: The suicide rate is high among bipolar disorder (BD) patients. Previous studies have focused on the anti-suicidal effect of long-term treatment with mood stabilizers but less on the immediate preventive effects of interventions. The aim of the study was to evaluate the short-term and immediate anti-suicidal effects of mood stabilizers on recent-onset BD patients. METHODS: The National Health Insurance Database (NHID) of Taiwan was used to perform a nationwide cohort observation study of suicide behaviors in bipolar disorder. All the recent-onset BD patients (ICD-9-CM code 296 except 296.2 and 296.3) diagnosed between 2000-2005 were collected (n=5091) and followed through 2009. The primary endpoint was the presence of a suicide code or the end of observation; exposure to mood stabilizers in the final month of observation was the independent variable. RESULTS: The hazard ratios (HRs) of suicide-related events, completed suicide, and all-cause mortality were significantly lower for those treated with lithium, divalproex, or carbamazepine compared with no use in the last month (HRs of suicide-related events were 0.10, 0.14 and 0.10, respectively, and all-cause mortality HRs were 0.03; P<0.0001); there was no significant difference in HR between the mood stabilizers. LIMITATIONS: The NIHD does not provide information on the severity, mood status, or treatment adherence of BD patients. Neither substance-related disorder nor personality disorder were included in the analysis. We focused on the effect of the final prescription time period, not the long-term protective effect. CONCLUSIONS: The immediate recent use of any mood stabilizer significantly lowers the rate of death, suicide, or suicidal behavior in BD.
    Date: 2016-05-15
    Relation: Journal of Affective Disorders. 2016 May 15;196:71-77.
    Link to: http://dx.doi.org/10.1016/j.jad.2016.02.014
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0165-0327&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000372716800008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84959340510
    Appears in Collections:[Others] Periodical Articles

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