國家衛生研究院 NHRI:Item 3990099045/9565
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9565


    Title: Prenatal exposure to perfluorocarboxylic acids (PFCAs) and fetal and postnatal growth in the Taiwan maternal and infant cohort study
    Authors: Wang, Y;Adgent, M;Su, PH;Chen, HY;Chen, PC;Hsiung, CA;Wang, SL
    Contributors: National Institute of Environmental Health Sciences;Division of Biostatistics and Bioinformatics
    Abstract: BACKGROUND: Perfluorocarboxylic acids (PFCAs) are environmentally and biologically persistent synthetic chemicals. PFCAs include perfluorooctanoic acid (PFOA, C8) and long-chain PFCAs (C9-C20). Studies examining long-chain PFCAs and fetal and postnatal growth are limited. OBJECTIVES: To investigate the associations of prenatal exposure to long chain PFCAs and fetal and postnatal growth. METHODS: For 223 Taiwanese mothers and their term infants, we measured PFOA and 4 long-chain PFCAs (ng/mL) in third trimester maternal serum; infant weight (kg), length and head circumference (cm) at birth; and childhood weight and height at approximately 2, 5, 8, and 11 years of age. For each sex, we used multivariable linear regression to examine associations between ln-transformed prenatal PFCAs and continuous infant measures, and logistic regression to examine small for gestational age (SGA). Linear mixed models were applied to prenatal PFCAs and childhood weight and height z-scores. RESULTS: In girls, prenatal perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDeA), perfluoroundecanoic acid (PFUnDA), and perfluorododecanoic acid (PFDoDA) concentrations were inversely associated with birth weight (e.g., betabirth weight (kg) = -0.06, 95% confidence interval [CI]: -0.11, -0.01 per 1 ln-unit PFUnDA increase); Prenatal PFDeA and PFUnDA were associated with elevated odds of SGA; and PFDeA, PFUnDA, and PFDoDA were associated with lower average childhood height z-score. In boys, prenatal PFNA, and PFDoDA were associated with reductions in height at certain ages in childhood, but not with size at birth. CONCLUSIONS: Prenatal exposure to long-chain PFCAs may interfere with fetal and childhood growth in girls, and childhood growth in boys.
    Date: 2016-11
    Relation: Environmental Health Perspectives. 2016 Nov;124(11):1794-1800.
    Link to: http://dx.doi.org/10.1289/ehp.1509998
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0091-6765&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000386913800025
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84994310470
    Appears in Collections:[Shu-Li Wang] Periodical Articles
    [Chao A. Hsiung] Periodical Articles

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