國家衛生研究院 NHRI:Item 3990099045/9599
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 913737      在线人数 : 1208
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9599


    题名: Longitudinal trajectory of allergen-specific IgE levels from prenatal stage to early life
    作者: Wang, JY;Chen, CA;Hou, YI;Hsiao, WL;Huang, YW;Tsai, YT;Tsai, HJ
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Background: Previous studies have suggested that children with immune-response alterations at birth have an increased risk of developing allergic diseases in early life. However, the longitudinal trajectory of allergen-specific IgE levels from the prenatal stage to early life has remained largely unexplored. Method: In this study, we measured 20 allergen-specific IgE levels using an automated microfluidic-based multiplexed immunoassay system (BioICTM Allergenspecific IgE Detection Kit- AD40 Panel; Agnitio Science and Technology, Hsinchu, Taiwan) and examined the relationship between 20 allergen-specific IgE levels (including: D. pteronyssinus, D. farinae, Blomia tropicalis, cat dander, dog dander, German cockroach, Bermuda grass, Timothy grass, ragweed, Aspergillus fumigatus, Candida albicans, egg white, milk, codfish, wheat, peanut, soybean, almond, crab and shrimp) in the blood samples of mothers, cord blood and infants at 12 months of age. Results: A significant level of agreement was observed for the 20 examined allergenspecific IgE levels in the blood samples of mothers, cord blood and infants at 12 months of age. The results from this study suggest that the influence of maternal allergen-specific IgE levels on infantimmune response might occur at birth and then wane in infants at 12 months of age in this Asian study sample. Conclusion: The findings suggest that the prenatal in utero environment influences IgE levels at birth. Our results further demonstrate that primary sensitization can occur transplacentally in utero, and that fetuses can respond to transplacental priming by making their own allergen-specific IgE, which is maintained at least until infants reach their first year of life.
    日期: 2015-09
    關聯: Allergy. 2015 Sep;70(Suppl. 101):286.
    Link to: http://dx.doi.org/10.1111/all.12718
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000369950701442
    显示于类别:[蔡慧如] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000369950701442.pdf59KbAdobe PDF485检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈