國家衛生研究院 NHRI:Item 3990099045/9614

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Title:	Multiple brain abscesses due to aspergillus fumigatus in a patient with liver cirrhosis: A case report
Authors:	Tang, HJ;Liu, WL;Chang, TC;Li, MC;Ko, WC;Wu, CJ;Chuang, YC;Lai, CC
Contributors:	Division of Infectious Diseases
Abstract:	Invasive cerebral aspergillosis always developed in immunocompromised host. Early diagnosis may save life in this critical condition; however, it is difficult to reach. Herein, we presented an unusual case of invasive cerebral aspergillosis in a cirrhotic patient.A 47-year-old man presented with progressive deterioration of consciousness for three days. The patient had a history of alcoholic liver cirrhosis, Child-Pugh class C. Magnetic resonance imaging (MRI) of brain showed multi-focal parenchymal lesions, which was consistent with multiple brain abscesses. The diagnosis of invasive cerebral aspergillosis was made by molecular based laboratory methods including Aspergillus galactomannan antigen assay and oligonucleotide array. Despite treatment with the antifungal agent, Amphotericin B, the patient died at the ninth day of hospitalization.Our findings suggest that liver cirrhosis can be one of risk factors of invasive cerebral aspergillosis, and support the diagnosing usefulness of MRI, Aspergillus galactomannan antigen assay, and oligonucleotide array.
Date:	2016-03
Relation:	Medicine. 2016 Mar;95(9):Article number e2813.
Link to:	http://dx.doi.org/10.1097/md.0000000000002813
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0025-7974&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000375208900047
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84962524397
Appears in Collections:	[Chi-Jung Wu] Periodical Articles

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