國家衛生研究院 NHRI:Item 3990099045/9675

NHRI > National Institute of Infectious Diseases and Vaccinology > Shih-Jen Liu > Periodical Articles > Item 3990099045/9675

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Title:	TGF-beta and IL-21 cooperatively stimulate activated CD8 T cells to differentiate into Tc17 cells
Other Titles:	TGF-β and IL-21 cooperatively stimulate activated CD8 T cells to differentiate into Tc17 cells
Authors:	Chen, HW;Tsai, JP;Yao, TY;Hsieh, CL;Chen, IH;Liu, SJ
Contributors:	Division of Vaccine Research and Development
Abstract:	TGF-beta together with IL-21 or IL-6 can drive the differentiation of naive CD8+ T cells into IL-17-producing CD8+ T cells. These IL-17-producing CD8+ T cells are termed Tc17 cells. Tc17 cells preserve plasticity under various conditions in vitro and in vivo. IFN-gamma-producing CD8+ T cells are termed Tc1 cells. However, Tc1 cells are considered relatively stable. In the present study, we show that the combination of TGF-beta plus IL-21, but not IL-6, converts Tc1 cells into Tc17 cells; this conversion is associated with elevated RORalpha, RORgammat, and Batf mRNA levels. These results indicate that Tc1 cells are skewed to the Tc17 cell phenotype under TGF-beta plus IL-21-polarizing conditions. Furthermore, IL-6R is expressed on naive, but not activated, CD8+ T cells. In contrast, IL-21R is expressed on both naive and activated CD8+ T cells. Thus, differential expression profiles of IL-6R and IL-21R on naive and activated CD8+ T cells may be one mechanism by which TGF-beta plus IL-21, but not IL-6, can drive activated CD8+ T cells to differentiate into IL-17-producing cells. Taken together, these results provide a novel viewpoint for the plasticity of Tc1 cells.
Date:	2016-06
Relation:	Immunology Letters. 2016 Jun;174:23-27.
Link to:	http://dx.doi.org/10.1016/j.imlet.2016.04.006
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0165-2478&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000377228500004
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84963731233
Appears in Collections:	[Shih-Jen Liu] Periodical Articles [Hsin-Wei Chen] Periodical Articles

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