國家衛生研究院 NHRI:Item 3990099045/9680

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9680

Title:	TPH1 and 5-HTTLPR genes specifically interact in opiate dependence but not in alcohol dependence
Authors:	Wang, TY;Lee, SY;Chung, YL;Chen, SL;Li, CL;Chang, YH;Wang, LJ;Chen, PS;Chen, SH;Chu, CH;Huang, SY;Tzeng, NS;Hsieh, TH;Lee, IH;Chen, KC;Yang, YK;Hong, JS;Lu, RB
Contributors:	Center for Neuropsychiatric Research
Abstract:	Background: Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence. Methods: Alcohol-dependent patients (n = 292), opiate-dependent patients (n = 309), and healthy controls (n = 301) were recruited from the Han Chinese population in Taiwan. Genotypes of TPH1 A218C and 5-HTTLPR polymorphisms were analyzed using a polymerase chain reaction with restriction fragment length polymorphism. Results: The genotype frequencies of the TPH1 A218C polymorphisms were not significantly different in the 3 groups. The genotype frequencies of the 5-HTTLPR S+ (S/S, S/LG, LG/LG) polymorphisms were significantly higher in opiate-dependent patients (χ2 = 8.77, p = 0.01), but not after controlling for the covariates of age, gender, and interaction effect in logistic regression analysis. Moreover, there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR S+ gene polymorphisms in opiate-dependent (OR 2.72, p = 0.01), but not in alcohol-dependent patients. Conclusions: Our data suggested that there may be a differential genetic vulnerability in serotonergic genes for alcohol and opiate addiction. However, replications of our findings are still needed.
Date:	2016-04
Relation:	European Addiction Research. 2016 Apr:201-209.
Link to:	http://dx.doi.org/10.1159/000444676
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1022-6877&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000377991900004
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84964089220
Appears in Collections:	[Others] Periodical Articles

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