國家衛生研究院 NHRI:Item 3990099045/9698
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9698


    Title: Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma
    Authors: He, HL;Lee, YE;Liang, PI;Lee, SW;Chen, TJ;Chan, TC;Hsing, CH;Chang, IW;Shiue, YL;Li, CF
    Contributors: National Institute of Cancer Research
    Abstract: PURPOSE: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. MATERIALS & METHODS: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. RESULTS: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. CONCLUSION: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.
    Date: 2016-08
    Relation: Future Oncology. 2016 Aug;12(16):1887-1896.
    Link to: http://dx.doi.org/10.2217/fon-2016-0025
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1479-6694&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000381030000007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84979508776
    Appears in Collections:[Others] Periodical Articles

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