國家衛生研究院 NHRI:Item 3990099045/9765
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    题名: Connecting the dots: From DNA damage and repair to Aging
    作者: Pan, MR;Li, K;Lin, SY;Hung, WC
    贡献者: National Institute of Cancer Research
    摘要: Mammalian cells evolve a delicate system, the DNA damage response (DDR) pathway, to monitor genomic integrity and to prevent the damage from both endogenous end exogenous insults. Emerging evidence suggests that aberrant DDR and deficient DNA repair are strongly associated with cancer and aging. Our understanding of the core program of DDR has made tremendous progress in the past two decades. However, the long list of the molecules involved in the DDR and DNA repair continues to grow and the roles of the new "dots" are under intensive investigation. Here, we review the connection between DDR and DNA repair and aging and discuss the potential mechanisms by which deficient DNA repair triggers systemic effects to promote physiological or pathological aging.
    日期: 2016-05-06
    關聯: International Journal of Molecular Sciences. 2016 May 6;17(5):Article number 685.
    Link to: http://dx.doi.org/10.3390/ijms17050685
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000378791400079
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84966389626
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