國家衛生研究院 NHRI:Item 3990099045/9778
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9778


    Title: Evaluation of blood flow in hepatocellular carcinoma: Assessment with computed tomography perfusion parameters and circulating angiogenic factors
    Authors: Chen, YW;Chou, CP
    Contributors: National Institute of Cancer Research
    Abstract: Purpose: To study the relationships between CT perfusion parameters and circulating angiogenic factors in patients with hepatocellular carcinoma (HCC). Materials and Methods: This study was HIPAA compliant and was approved by the institutional review board. All participants provided informed consents. CT perfusion parameters of HCCs among 21 patients were assessed using 21-phase liver images at a 64-slice multidetector CT. We analyzed CT perfusion parameters including total blood flow, arterial blood flow, portal blood flow and arterial fraction (arterial blood flow /total blood flow) of HCCs, surrounding liver parenchyma and HCC-parenchyma ratio. Interleukin 6 (IL-6), interleukin 8 (IL-8), vascular endothelial growth factor (VEGF), and platelet derived growth factor (PDGF) in plasma were measured using Bio-Plex multiplex immunoassay in 21 HCC patients and 8 healthy controls. Result: CT perfusion parameters of HCCs showed statistically different from that of surrounding liver parenchyma in total blood flow (p=0.002), portal blood flow (p<0.001) and arterial fraction (p<0.001). Circulating IL-6, IL-8 and VEGF showed significantly higher levels in HCC patients than controls (p<0.05), and predicted HCC significantly better than chance (p<0.001). None of circulating angiogenic factors had significant correlation with any of CT perfusion parameters in HCC patients. Only HCC-parenchyma ratio of arterial blood flow showed significant positive correlation with circulating IL-8 (p<0.05). Conclusion: CT perfusion parameters of HCC and circulating angiogenic factors are useful tools for HCC diagnosis. Only circulating IL-8 and HCC-parenchyma ratio of arterial blood flow showed significant correlation.
    Date: 2011-04
    Relation: Cancer Research. 2011 Apr;71:Abstract number 291.
    Link to: http://dx.doi.org/10.1158/1538-7445.am2011-291
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000209701304487
    Appears in Collections:[Ya-Wen Chen] Conference Papers/Meeting Abstract

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