國家衛生研究院 NHRI:Item 3990099045/9781
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    题名: Dicer elicits paclitaxel chemosensitization and suppresses cancer stemness in breast cancer by repressing AXL
    作者: Chang, TY;Chen, HA;Chiu, CF;Chang, YW;Kuo, TC;Tseng, PC;Wang, W;Hung, MC;Su, JL
    贡献者: National Institute of Cancer Research
    摘要: Paclitaxel is a standard-of-care chemotherapy for breast cancer, despite the increasing recognition of its poor effectiveness in the treatment of patients with advanced disease. Here we report that adenovirus type 5 E1A-mediated elevation of the microRNA processing enzyme Dicer is sufficient to enhance paclitaxel sensitization and reduce cancer stem-like cell properties in this setting. Elevating Dicer expression increased levels of the AXL kinase targeting microRNA miR-494, thereby repressing AXL expression to increase paclitaxel sensitivity. We found that Dicer expression was regulated at the transcription level by E1A, through activation of a MAPK14/CEBPalpha pathway. Our findings define a mechanism of E1A-mediated chemosensitization for paclitaxel which is based upon the suppression of breast cancer stem-like cells, with potential implications for the diagnosis and treatment of breast cancer patients.
    日期: 2016-07
    關聯: Cancer Research. 2016 Jul;76(13):3916-3928.
    Link to: http://dx.doi.org/10.1158/0008-5472.can-15-2555
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000380071400027
    https://www.webofscience.com/wos/woscc/full-record/WOS:000380071400027
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84977522315
    显示于类别:[蘇振良] 期刊論文

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