國家衛生研究院 NHRI:Item 3990099045/9791
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    题名: Dietary diversity no longer offsets the mortality risk of hyperhomocysteinaemia in older adults with diabetes: A prospective cohort study
    其它题名: 飲食多樣性無法抵銷高同半胱氨酸血症老年糖尿病患者的死亡風險：一個前瞻性世代研究
    作者: Wahlqvist, ML;Xiu, L;Lee, MS;Chen, RC;Chen, KJ;Li, D
    贡献者: Division of Health Services and Preventive Medicine
    摘要: BACKGROUND AND OBJECTIVE: The increased mortality risk of hyperhomocysteinaemia in diabetes may be mitigated by dietary quality. METHODS AND STUDY DESIGN: The Nutrition and Health Survey in Taiwan of 1999-2000 for elders formed this prospective cohort. Baseline health status, diet and anthropometry were documented and plasma homocysteine and biomarkers for B vitamins measured. Participants without diabetes (n=985) were referent for those who had diabetes or developed diabetes until 2006 (n=427). The effect of homocysteine on mortality risk during 1999-2008 was evaluated. RESULTS: Men, smokers and those with poorer physical function had higher homocysteine, but less so with diabetes. Diabetes incidence was unrelated to homocysteine. In hyperhomocysteinaemia (>=15 vs <15 mumol/L), those with diabetes had an adjusted hazard ratio (HR) (95% CI) for mortality of 1.71 (1.18-2.46); p for interaction between homocysteine and diabetes was 0.005. Without diabetes, but with hyperhomocysteinaemia and a low dietary diversity score (DDS <=4 of 6), where the joint mortality hazard for the greater DDS, (>4) and lower homocysteine (<15) was referent, the HR was 1.80 (1.27-2.54) with significant interaction (p=0.008); by contrast, there was no joint effect with diabetes. The contribution of DDS to mortality mitigation in hyperhomocysteinaemia could not be explained by B group vitamins, even though plasma folate was low in hyperhomocysteinaemic participants. With hyperhomocysteinaemia, heart failure was a major cause of death. CONCLUSIONS: In non-diabetic hyperhomocysteinaemia, a more diverse diet increases survival prospects independent of B group vitamins, but not in hyperhomocysteinaemic diabetes where the cardiomyopathy may be less responsive.
    日期: 2016-06-01
    關聯: Asia Pacific Journal of Clinical Nutrition. 2016 Jun 1;25(2):414-423.
    Link to: http://dx.doi.org/10.6133/apjcn.112015.06
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-7058&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000377051000023
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84979093876
    显示于类别:[MARK LAWRENCE WAHLQVIST(2008-2012)] 期刊論文

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