國家衛生研究院 NHRI:Item 3990099045/9797
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 857812      線上人數 : 833
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9797


    題名: Early Helicobacter pylori eradication associated with reduced risk of gastric cancer in peptic ulcer disease
    作者: Wu, CY;Kuo, K;Wu, MS;Wang, CB;Lin, JT
    貢獻者: Division of Health Services and Preventive Medicine;Division of Geriatric Research
    摘要: Background: Helicobacter pylori (H. pylori) is the major determinant of environmental risk for gastric cancer. Although a link has been established between H. pylori and gastric cancer in animal models, results of clinical studies remain controversial. Methods: We conducted a nationwide cohort study based on data from 80,255 patients with H. pylori-infected peptic ulcer diseases over a 10-year period obtained from the Taiwan National Health Insurance Database (NHID). Patients were divided into early (H. pylori eradication within the first year of the index admission) and late eradication cohorts. Standardized incidence ratios (SIRs) and cumulative incidences were analyzed. Results: Early eradication cohort had significantly lower risk of development of gastric cancer (SIR=1.05, 95% CI: 0.96-1.14) than late eradication cohort (SIR=1.36, 95% CI: 1.24-1.49). In early eradication cohort, the SIR of gastric ulcer patients declined from 1.60 at 3 to 4 years to 1.05 at 7 to 10 years after index hospitalization. Over the same periods, the SIR of duodenal ulcer patients declined from 0.57 to 0.33. In late eradication cohort, similar trends were observed. The SIRs decreased from 2.14 to 1.32 for patients with gastric ulcer and from 0.90 to 0.66 for patients with duodenal ulcer. Early H. pylori eradication was also associated with lower risk of gastric cancer in patients regularly receiving aspirin or NSAIDs, as well as in patients who are not. Conclusions: H. pylori eradication therapy should be carried out as soon as possible in patients with peptic ulcer diseases to prevent gastric cancer development.
    日期: 2009-05
    關聯: Cancer Research. 2009 May;69:Abstract number 2156.
    Link to: http://cancerres.aacrjournals.org/content/69/9_Supplement/2156.abstract
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000209702704099
    顯示於類別:[林肇堂] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000209702704099.pdf15KbAdobe PDF392檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋