國家衛生研究院 NHRI:Item 3990099045/9845
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9845


    Title: ABCG2 overexpression confers poor outcomes in hepatocellular carcinoma of elderly patients
    Authors: Chen, YL;Chen, PM;Lin, PY;Hsiau, YT;Chu, PY
    Contributors: National Institute of Cancer Research
    Abstract: Backgroung/Aim: Breast cancer resistance protein [BCRP/ATP-binding cassette subfamily G member 2 (ABCG2)] is a member of the ATP-binding cassette transporter family, used as a maker of cancer stem cells (CSCs) and thought to be responsible for drug resistance by pumping them out of cells. However, its precise role in various cancer types has been controversial, and the aim of this study was to investigate the expression of ABCG2 in hepacellular carcinoma (HCC) and relate the results to established prognostic factors. PATIENTS AND METHODS: We conducted analysis of 181 HCC and paired-match adjacent normal liver tissue by immunohistochemistry from tissue array of slides. RESULTS: The mean score for ABCG2 expression was higher in tumor than in adjacent normal liver tissue of HCC patients (p<0.001). There was a statistically significant correlation between ABCG2 expression and age, differentiation status and hepatitis B surface antigen (p=0.031, p=0.015 and p=0.033, respectively). Additionally, increased expression of ABCG2 in HCC and its statistically significant correlation with hepatitis B surface antigen was found in elderly (p=0.039), not in younger patients (p=0.518). Importantly, by using Kaplan-Meier and Cox regression analysis, overall survival in patients with high expression of ABCG2 was found reduced in elderly patients (p=0.029 and p=0.081, respectively). CONCLUSION: ABCG2 can be used as a target for the development of novel therapies in HCC.
    Date: 2016-06
    Relation: Anticancer Research. 2016 Jun;36(6):2983-2988.
    Link to: http://ar.iiarjournals.org/content/36/6/2983.abstract
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-7005&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000377464200044
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84991677291
    Appears in Collections:[Others] Periodical Articles

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