國家衛生研究院 NHRI:Item 3990099045/9874

NHRI > Institute of Biotechnology and Pharmaceutical Research > Shiow-Ju Lee > Periodical Articles > Item 3990099045/9874

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9874

Title:	Cytotoxic cardenolides and sesquiterpenoids from the fruits of Reevesia formosana
Authors:	Hsiao, PY;Lee, SJ;Chen, IS;Hsu, HY;Chang, HS
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Bioassay-guided fractionation of the fruits of Reevesia formosana led to isolation of three cardenolides (reevesioside J, reevesioside K, and epi-reevesioside K), three sesquiterpenoids (reevesiterpenol C, reevesiterpenol D, and reevesiterpenol E), and two glycosides (reevesianin A and reevesianin B), along with 46 known compounds. Their structures were determined using spectroscopic techniques. In addition to the reported cytotoxic cardenolides, reevesioside J and strophanthidin exhibited moderate cytotoxicity against the cell lines MCF-7, NCI-H460, and HepG2, with IC50 values of 0.39 ± 0.06 μM and 1.06 ± 0.12 μM for MCF-7, 0.12 ± 0.01 μM and 0.29 ± 0.01 μM for NCI-H460, and 1.09 ± 0.02 μM and 1.72 ± 0.02 μM for HepG2, respectively. Reevesiterpenol E also exhibited the best selective cytotoxicity to the NCI-H460 cell line, with an IC50 value of 3.15 ± 0.22 μM.
Date:	2016-10
Relation:	Phytochemistry. 2016 Oct;130:282-290.
Link to:	http://dx.doi.org/10.1016/j.phytochem.2016.06.009
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0031-9422&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000383302900028
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84977125909
Appears in Collections:	[Shiow-Ju Lee] Periodical Articles

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