國家衛生研究院 NHRI:Item 3990099045/9937
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 857268      線上人數 : 352
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9937


    題名: DUB-3 regulation of tumor associated inflammation and tumor growth
    作者: Lu, CH;Yeh, DW;Lai, CY;Liu, YL;Chuang, TH
    貢獻者: Immunology Research Center
    摘要: The tumor microenvironment includes blood vessels, immune cells, fibroblasts, and tumor cells. Inflammation in tumor microenvironment leads to the initiation, promotion, invasion, and metastasis of cancer. Inflammation stimuli such as TNF-α, IL-1β and TLR ligands are capable of activating the NF-κB controlled inflammatory signaling in cancer cells. The activations by these stimuli are modulated by various signaling molecules including those control ubiquitination and deubiquitination in the NF-κB signaling pathway. The DUB-3, has been identified as a deubiquitinating enzyme that belongs to cytokine inducible DUBs. In this study, we investigated the function of DUB-3 in control of inflammatory responses in different cancer cells. Expression of DUB-3 in these cancer cells regulated IL-1β, LPS, and Pam3Cys induced cytokine and chemokine productions and generated favorable conditions for tumor growth. DUB-3 promoted in vivo tumorigenesis and tumor growth. H&E staining of tumor sections revealed higher leukocyte infiltration in the tumors. The expression of genes associated with inflammation were investigated, and higher expression of inflammatory cytokines and chemokines were observed in tumors. Taken together, these observations suggest that DUB-3 regulates tumor growth by modulating inflammatory associated function.
    日期: 2016-05
    關聯: Journal of Immunology. 2016 May;196(1 Suppl.):Meeting Abstract 73.16.
    Link to: http://www.jimmunol.org/content/196/1_Supplement/73.16
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-1767&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000380288301246
    顯示於類別:[莊宗顯] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000380288301246.pdf22KbAdobe PDF415檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋