國家衛生研究院 NHRI:Item 3990099045/9975
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    题名: Superparamagnetic gadolinium ferrite nanoparticles with controllable curie temperature – cancer theranostics for MR-imaging-guided magneto-chemotherapy
    作者: Thorat, ND;Bohara, RA;Tofail, SAM;Alothman, ZA;Shiddiky, MJA;A Hossain, MS;Yamauchi, Y;Wu, KCW
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: A facile polyol approach for preparing low-Curie-temperature (TC) gadolinium-doped iron oxide nanoparticles (GdIO NPs) for targeted magnetic hyperthermia and chemotherapy coupled with T1–T2 dual-model magnetic resonance (MR) imaging (where T1 and T2 are the longitudinal and transverse relaxation times, respectively) is reported. A small amount of Gd doping decreases the TC of iron oxide down to about 400 K. In the presence of ethanolamine, controlled polyol synthesis leads to the formation of low-TC, highly magnetic (52.87 emu g–1), and size-controlled (ca. 10 nm) GdIO NPs. A further conjugation with folate and a chemotherapeutic drug has been developed, and the whole system is used for in vitro magneto-chemotherapy (magnetic hyperthermia and chemotherapy) for cancer treatment. The synthesized GdIO NPs are stable colloids that are hemocompatible and cytocompatible over a wide concentration range and have a high affinity towards cancer cells. The release of a chemotherapeutic drug from the GdIO NPs significantly affects cancer cell viability, and the T1–T2 dual-model magnetic resonance enhances bioimaging in a breast cancer cell model. We suggest that the chemotherapeutic-drug-conjugated GdIO NPs have great potential for cell targeting and magnetic resonance imaging in cancer magneto-chemotherapy.
    日期: 2016-10
    關聯: European Journal of Inorganic Chemistry. 2016 Oct;2016(28):4586-4597.
    Link to: http://dx.doi.org/10.1002/ejic.201600706
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1434-1948&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000386169600010
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84984706719
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