國家衛生研究院 NHRI:Item 3990099045/9980
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    題名: Organic nanoparticles with aggregation-induced emission for Bone Marrow Stromal Cell tracking in a rat PTI model
    作者: Cai, X;Zhang, CJ;Ting Wei Lim, F;Chan, SJ;Bandla, A;Chuan, CK;Hu, F;Xu, S;Thakor, NV;Liao, LD;Liu, B
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Stem-cell based therapy is an emerging therapeutic approach for ischemic stroke treatment. Bone marrow stromal cells (BMSCs) are in common use as a cell source for stem cell therapy and show promising therapeutic outcomes for stroke treatment. One challenge is to develop a reliable tracking strategy to monitor the fate of BMSCs and assess their therapeutic effects in order to improve the success rate of such treatment. Herein, TPEEP, a fluorogen with aggregation-induced emission characteristics and near-infrared emission are designed and synthesized and further fabricated into organic nanoparticles (NPs). The obtained NPs show high fluorescence quantum yield, low cytotoxicity with good physical and photostability, which display excellent tracking performance of BMSCs in vitro and in vivo. Using a rat photothrombotic ischemia model as an example, the NP-labeled BMSCs are able to migrate to the stroke lesion site to yield bright red fluorescence. Immunofluorescence staining shows that the NP labeling does not affect the normal function of BMSCs, proving their good biocompatibility in vivo. These merits make TPEEP NP a potential cell tracker to evaluate the fate of BMSCs in cell therapy.
    日期: 2016-12
    關聯: Small. 2016 Dec;12(47):6576-6585.
    Link to: http://dx.doi.org/10.1002/smll.201601630
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1613-6810&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000393220700014
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84984911575
    顯示於類別:[廖倫德] 期刊論文

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