國家衛生研究院 NHRI:作者相关文件

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"Lin, WH"的相关文件

类别	日期	题名	關聯
[伍素瑩] 期刊論文	2019-04-10	Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants	-
[伍素瑩] 期刊論文	2016-04-12	Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK)	-
[何令君] 期刊論文	2015-01	Modulation of both activator protein-1 and nuclear factor-kappa B signal transduction of human T cells by amiodarone	-
[其他] 期刊論文	2022-05-20	Left frontotemporal region plays a key role in letter fluency task-evoked activation and functional connectivity in normal subjects: A functional near-infrared spectroscopy study	-
[其他] 期刊論文	2021-06	Network reorganization during verbal fluency test in fronto-temporal epilepsy: A functional near-infrared spectroscopy study	-
[其他] 期刊論文	2019-08	The effect of antidementia drugs on mortality in patients with Alzheimer's disease	-
[廖本揚] 期刊論文	2019-03-13	Genome-wide microarray analysis suggests transcriptomic response may not play a major role in high- to low-altitude acclimation in harvest mouse (Micromys minutus)	-
[張俊彥] 會議論文/會議摘要	2011-05	Pharmacokinetic study with novel anticanacer agents, MPTOB124 and MPTOB214	-
[張俊彥] 期刊論文	2011-08	BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells	-
[張俊彥] 期刊論文	2008-02	A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells	-
[張堯] 期刊論文	2013-02	Epstein-Barr virus Zta upregulates matrix metalloproteinases 3 and 9 that synergistically promote cell invasion in vitro	-
[張堯] 期刊論文	2012-06	Epstein-Barr virus latent membrane protein 2A promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated induction of matrix metalloproteinase 9	-
[彭汪嘉康(1996-2007)] 期刊論文	2001-09-01	Inverted repeats as genetic elements for promoting DNA inverted duplication: implications in gene amplification	-
[彭汪嘉康(1996-2007)] 期刊論文	2001-08-15	Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system	-
[徐祖安] 期刊論文	2015-01	Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity	-
[徐祖安] 期刊論文	2014-05	Cover Picture: Facile identification of dual FLT3–aurora a inhibitors: A computer-guided drug design approach (ChemMedChem 5/2014)	-
[徐祖安] 期刊論文	2014-01-08	Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer	-
[徐祖安] 期刊論文	2013-09-22	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment [Erratum:International Journal of Biological Sciences. 2013 Apr 29;9(4):403-411]	-
[徐祖安] 期刊論文	2013-05	Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors	-
[徐祖安] 期刊論文	2013-04-29	A novel Aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment	-
[徐祖安] 期刊論文	2012-01	BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML	-
[徐祖安] 期刊論文	2012-01	A High-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors	-
[徐祖安] 期刊論文	2011-06-01	Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells	-
[徐祖安] 期刊論文	2011-04-25	Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virus	-
[李俊賢] 期刊論文	2012-11	Estimation of expected life-years saved from successful prevention of end-stage renal disease in elderly patients with diabetes: A nationwide study from Taiwan	-
[李岳倫] 期刊論文	2021-01-15	Unlocking the mystery of the therapeutic effects of Chinese medicine on cancer	-
[李秀珠] 期刊論文	2020-08	Repurposing old drugs as antiviral agents for coronaviruses	-
[林嬪嬪] 期刊論文	2006-01-05	Increased cytochrome P4501B1 gene expression in peripheral leukocytes of municipal waste incinerator workers	-
[林景太(1999-2007)] 期刊論文	2006-10-15	DNA mismatch repair as an effector for promoting phorbol ester-induced apoptotic DNA damage and cell killing: Implications in tumor promotion	-
[楊重熙] 期刊論文	2014-04	Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies	-
[江宏哲] 期刊論文	2016-06-01	A RISK21 matrix for assessing the potential health risk of DDT from flower tea in Taiwan	-
[石全(2014-2017)] 會議論文/會議摘要	2020-08	BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification	-
[紀雅惠] 會議論文/會議摘要	2019-07	An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer	-
[紀雅惠] 期刊論文	2021-05-19	Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins	-
[紀雅惠] 期刊論文	2019-12	Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis	-
[紀雅惠] 期刊論文	2018-05-10	Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition	-
[葉燈光] 會議論文/會議摘要	2019-10	Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer	-
[葉燈光] 會議論文/會議摘要	2017-04	Discovery of BPR1K871-a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[蔣維棠] 專利	2014-04-21	作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途	-
[蔣維棠] 期刊論文	2019-12	Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia	-
[蔣維棠] 期刊論文	2015-07	Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations	-
[蔣維棠] 期刊論文	2013-06	Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	-
[蔣維棠] 期刊論文	2012-06-07	3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	-
[蔣維棠] 期刊論文	2011-07	Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	-
[謝興邦] 專利	2015-07-22	作为酪胺酸激酶抑制剂的稠合双环及多环嘧啶化合物	-
[謝興邦] 專利	2013-08-13	Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors	-
[謝興邦] 專利	2013-02-11	作為酪胺酸激酶抑制劑之稠合雙環及多環嘧啶化合物	-
[謝興邦] 會議論文/會議摘要	2014-10	Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML	-
[謝興邦] 會議論文/會議摘要	2014-10	Novel irreversible EGFR tyrosine kinase inhibitor, DBPR112, as a therapeutic candidate for lung adenocarcinoma	-
[謝興邦] 會議論文/會議摘要	2014-03	Efficient virtual screening using ligand efficiency based approach	-
[謝興邦] 會議論文/會議摘要	2013-04-07	3D-QSAR assisted drug design: Identification of a potent quinazoline based Aurora kinase inhibitor	-
[謝興邦] 會議論文/會議摘要	2013-04	Design and synthesis of Aurora kinase inhibitors as anticancer agents	-
[謝興邦] 會議論文/會議摘要	2012-03-25	Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors	-
[謝興邦] 會議論文/會議摘要	2011-09-23	BPR1K653, a novel Aurora Kinase Inhibitor, exhibits potent anti-proliferative activity in P-gp170 (MDR1)-mediated VX680-resistant cancer cells in vitro and in vivo	-
[謝興邦] 會議論文/會議摘要	2010-08	Lead optimization of furanopyrimidine Aurora kinase inhibitors: Development of in vivo active agents in tumor xenograft models	-
[謝興邦] 會議論文/會議摘要	2009-09	Fast-forwarding kinase drug discovery: aurora and EGFR kinase inhibitor lead development	-
[謝興邦] 會議論文/會議摘要	2009-03	Discovery and development of novel furano-pyrimidine analogs as Aurora kinase inhibitors	-
[謝興邦] 期刊論文	2024-06-24	Discovery of dual MER/AXL kinase inhibitors as bifunctional small molecules for inhibiting tumor growth and enhancing tumor immune microenvironment	-
[謝興邦] 期刊論文	2021-11-15	Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization	-
[謝興邦] 期刊論文	2021-10-14	Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model	-
[謝興邦] 期刊論文	2020-05	Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors	-
[謝興邦] 期刊論文	2019-11-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	-
[謝興邦] 期刊論文	2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	-
[謝興邦] 期刊論文	2016-11-29	Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design	-
[謝興邦] 期刊論文	2015-06-29	Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification	-
[謝興邦] 期刊論文	2014-08	Ligand efficiency based approach for efficient virtual screening of compound libraries	-
[謝興邦] 期刊論文	2014-05	Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach	-
[謝興邦] 期刊論文	2013-06-28	Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor	-
[謝興邦] 期刊論文	2013-05	Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	-
[謝興邦] 期刊論文	2013-01	3D-QSAR-assisted drug design: Identification of a potent quinazoline-based aurora kinase inhibitor	-
[謝興邦] 期刊論文	2010-06-15	Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification	-
[謝興邦] 期刊論文	2010-02-01	Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor	-
[謝興邦] 期刊論文	2009-04-23	Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists	-
[謝興邦] 期刊論文	2009-02-26	Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity	-
[謝興邦] 期刊論文	2008-03-01	Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold	-
[謝興邦] 期刊論文	2006-07	Antiviral drug discovery against SARS-CoV	-
[趙宇生(2002-2013)] 會議論文/會議摘要	2012-11	BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia	-
[趙宇生(2002-2013)] 期刊論文	2010-10-28	Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and michael acceptor group for maximal potency	-
[趙宇生(2002-2013)] 期刊論文	2010-10	Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists	-
[邱燕楓] 期刊論文	2010-08	SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes	-
[陳怡榮] 期刊論文	2008-06-01	A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors	-
[陳炯東] 會議論文/會議摘要	2016-12	Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST	-
[陳炯東] 會議論文/會議摘要	2015-08	Optimization of quinazoline-based kinase inhibitors: Identification of a dual FLT3/AURKA kinase inhibitor for the treatment of acute myeloid leukemia	-
[陳炯東] 期刊論文	2020-08	Artificial intelligence approach fighting COVID-19 with repurposing drugs	-
[陳立宗] 期刊論文	2022-04	Assessment of hyperprogression versus the natural course of disease development with nivolumab with or without ipilimumab versus placebo in phase III, randomized, controlled trials	-

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