English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12441/13613 (91%)
造訪人次 : 2357298      線上人數 : 121
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    主頁登入上傳說明關於NHRI管理 到手機版
    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10273


    題名: Serum uric acid levels and 20-year cardiovascular mortality: dual pathways of hemodynamics and renal function
    作者: Hsu, PF;Cheng, HM;Sung, SH;Chuang, SY;Yin, F;Lakatta, ED;Chou, P;Chen, CH
    貢獻者: Division of Health Services and Preventive Medicine
    摘要: Background: The pathways between serum uric acid (UA) levels and future cardiovascular events remain unclear. We studied the contributions of conventional risk factors, hemodynamics, and renal function to the relationship between UA and cardiovascular mortality among generally healthy treatment naïve adults. Methods: A cohort of 624 normotensive and 633 untreated hypertensive Taiwanese participants (overall 669 men, aged 30–79 years) with complete demographic, cardiovascular, and biochemistry studies was drawn from a community-based survey. Fatal cardiovascular events within 20 years' follow-up (n=90) were ascertained with National Death Registry database. Results: UA correlated significantly with brachial systolic blood pressure (SBP) (r = 0.240, P<0.01) and estimated glomerular filtration rate (eGFR) (r=-0.423, P<0.01). In univariate Cox analysis, UA, SBP, and eGFR significantly predicted cardiovascular mortality [hazard ratios per 1SD and 95% confidence intervals: 1.37 (1.14–1.65), 2.26 (1.88–2.71), 0.42 (0.34–0.52), respectively]. SBP or eGFR but not UA was significantly predictive of cardiovascular mortality, in bi-variate and tri-variate analysis. In contrast, in a multivariate Cox model adjusted for age, sex, smoking, total cholesterol, high-density lipoprotein cholesterol, and fasting plasma glucose, UA was significantly independently predictive of cardiovascular mortality [1.26 (1.02–1.56)]. Conclusions: UA lost predictive power for cardiovascular mortality when either SBP or eGFR was added to the prediction models. Both hemodynamics and renal function are important pathways between the UA and cardiovascular mortality relationship.
    日期: 2016-08
    關聯: European Heart Journal. 2016 Aug;37(Suppl. 1):1333.
    Link to: https://academic.oup.com/eurheartj/issue/37/suppl_1
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0195-668X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000383869506453
    顯示於類別:[莊紹源] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000383869506453.pdf145KbAdobe PDF884檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋