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http://ir.nhri.org.tw/handle/3990099045/10926
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| Title: | Trends in Carbapenemase-producing Klebsiella pneumoniae, Taiwan, 2012-2015 |
| Authors: | Chiu, SK;Ma, L;Chan, MC;Fung, CP;Wu, TL;Chuang, YC;Lu, PL;Wang, JT;Lin, JC;Yeh, KM |
| Contributors: | National Institute of Infectious Diseases and Vaccinology |
| Abstract: | Background: Before 2011, the prevalence rates of carbapenemaseproducing Klebsiella pneumoniae (CPKP) among carbapenem nonsusceptible K. pneumoniae (CnSKP) isolates were below 10% in Taiwan. We present the dissemination trends of CPKP from January 2012 to August 2015. Methods: Twenty-one hospitals in Taiwan were enrolled in the study. K. pneumoniae isolates with minimum inhibitory concentrations (MICs) of >1 mg/L for imipenem or meropenem were collected for carbapenemase genes screening and antimicrobial susceptibility testing. Results: A total of 1457 CnSKP isolates were collected and screened for carbapenemase genes, and tested for antimicrobial susceptibility. Among 457 CPKP isolates, three classes of carbapenemase genes were identified: class A (319 KPC-2, 2 KPC-3, 28 KPC-17, 2 KPC-25), class B (27 IMP-8, 38 VIM-1, 4 NDM-1), and class D (43 OXA-48). Among them, KPC-3, −17, −25, and OXA-48 were emerging during this period. The prevalence of CPKP increased from 24.1% in 2012 to 36.8% in 2015 and was as high as 70.3% in the west in 2015. Conclusion: This study depicts an ominous scenario of these highly resistant organisms, highlighting the enhanced infection control measures are required. |
| Date: | 2017-11 |
| Relation: | International Journal of Antimicrobial Agents. 2017 Nov;50(Suppl. 2):S116. |
| Link to: | http://dx.doi.org/10.1016/S0924-8579(17)30423-5 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000416028900273 |
| Appears in Collections: | [其他] 會議論文/會議摘要
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| ISI000416028900273.pdf | 74Kb | Adobe PDF | 297 | View/Open |
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