國家衛生研究院 NHRI:Item 3990099045/1116

NHRI > Institute of Biotechnology and Pharmaceutical Research > Shiow-Ju Lee > Periodical Articles > Item 3990099045/1116

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1116

Title:	Benzothiazolium compounds: Novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFN gamma
Authors:	Tseng, HY;Wu, SH;Huang, WH;Wang, SF;Yang, YN;Mahindroo, N;Hsu, T;Jiaang, WT;Lee, SJ
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	A series of benzothiazolium compounds were identified as novel classes of inhibitors of nitric oxide production in a cell culture system. They exhibited similar to 1600 folds potency with IC50 at similar to 50 nM to several mu M as compared to IC50 88.4 mu M of L-NMMA, a known inhibitor of nitric oxide synthase. The mechanistic studies suggest that decreased iNOS protein synthesis and mRNA transcription, at least in part, were related to the inhibitory activity of effective benzothiazolium compounds. The correlation of in vivo and in vitro activities using mouse paw edema model was also demonstrated.
Keywords:	Chemistry, Medicinal;Chemistry, Organic
Date:	2005-04-15
Relation:	Bioorganic and Medicinal Chemistry Letters. 2005 Apr;15(8):2027-2032.
Link to:	http://dx.doi.org/10.1016/j.bmcl.2005.02.063
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000228432900014
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=15944403641
Appears in Collections:	[Shiow-Ju Lee] Periodical Articles [Weir-Torn Jiaang] Periodical Articles

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