國家衛生研究院 NHRI:Item 3990099045/1116
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    题名: Benzothiazolium compounds: Novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFN gamma
    作者: Tseng, HY;Wu, SH;Huang, WH;Wang, SF;Yang, YN;Mahindroo, N;Hsu, T;Jiaang, WT;Lee, SJ
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: A series of benzothiazolium compounds were identified as novel classes of inhibitors of nitric oxide production in a cell culture system. They exhibited similar to 1600 folds potency with IC50 at similar to 50 nM to several mu M as compared to IC50 88.4 mu M of L-NMMA, a known inhibitor of nitric oxide synthase. The mechanistic studies suggest that decreased iNOS protein synthesis and mRNA transcription, at least in part, were related to the inhibitory activity of effective benzothiazolium compounds. The correlation of in vivo and in vitro activities using mouse paw edema model was also demonstrated.
    关键词: Chemistry, Medicinal;Chemistry, Organic
    日期: 2005-04-15
    關聯: Bioorganic and Medicinal Chemistry Letters. 2005 Apr;15(8):2027-2032.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2005.02.063
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000228432900014
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=15944403641
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