國家衛生研究院 NHRI:Item 3990099045/1133
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1133


    Title: Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives
    Authors: Chern, JH;Shia, KS;Chang, CM;Lee, CC;Lee, YC;Tai, CL;Lin, YT;Chang, CS;Tseng, HY
    Contributors: Division of Biotechnology and Pharmaceutical Research;Division of Molecular and Genomic Medicine
    Abstract: A series of 5-substituted 2-eyanoimino-4-imidazodinone and 2-eyanoimino-4-pyrimidinone derivatives were synthesized and their anticancer cytotoxicity were evaluated in in vitro assay. It was found that the bulky aryl functionality in the 5-position of the 2-cyanoimino-4-imidazolidinone compounds was essential for the cytotoxicity of these heterocyclic compounds. Some of the derivatives exhibited modest cytotoxicity against a variety of cancer cell lines. One of the derivatives, [1-[6-(4-chlorophenoxy)hexyl]-5-oxo-4-phenyl-3-(4-pyridyl)tetrahydro-1H-2-imidazolyliden]aminomethanenitrile (Compound 11), exhibited the most potent cytotoxic activity with IC50 in the nanomolar range. The cytotoxicity of these derivatives was selection with no apparent toxic effect toward normal fibroblasts. (C) 2003 Elsevier Ltd. All rights reserved.
    Keywords: Chemistry, Medicinal;Chemistry, Organic
    Date: 2004-03-08
    Relation: Bioorganic and Medicinal Chemistry Letters. 2004 Mar;14(5):1169-1172.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2003.12.073
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000189314800021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1242294354
    Appears in Collections:[Kak-Shan Shia] Periodical Articles
    [Jyh-Haur Chern] Periodical Articles
    [Chung-Ming Chang] Periodical Articles

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