國家衛生研究院 NHRI:Item 3990099045/1133
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    题名: Synthesis and in vitro cytotoxicity of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives
    作者: Chern, JH;Shia, KS;Chang, CM;Lee, CC;Lee, YC;Tai, CL;Lin, YT;Chang, CS;Tseng, HY
    贡献者: Division of Biotechnology and Pharmaceutical Research;Division of Molecular and Genomic Medicine
    摘要: A series of 5-substituted 2-eyanoimino-4-imidazodinone and 2-eyanoimino-4-pyrimidinone derivatives were synthesized and their anticancer cytotoxicity were evaluated in in vitro assay. It was found that the bulky aryl functionality in the 5-position of the 2-cyanoimino-4-imidazolidinone compounds was essential for the cytotoxicity of these heterocyclic compounds. Some of the derivatives exhibited modest cytotoxicity against a variety of cancer cell lines. One of the derivatives, [1-[6-(4-chlorophenoxy)hexyl]-5-oxo-4-phenyl-3-(4-pyridyl)tetrahydro-1H-2-imidazolyliden]aminomethanenitrile (Compound 11), exhibited the most potent cytotoxic activity with IC50 in the nanomolar range. The cytotoxicity of these derivatives was selection with no apparent toxic effect toward normal fibroblasts. (C) 2003 Elsevier Ltd. All rights reserved.
    关键词: Chemistry, Medicinal;Chemistry, Organic
    日期: 2004-03-08
    關聯: Bioorganic and Medicinal Chemistry Letters. 2004 Mar;14(5):1169-1172.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2003.12.073
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000189314800021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1242294354
    显示于类别:[夏克山] 期刊論文
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