國家衛生研究院 NHRI:Item 3990099045/11725

NHRI > Institute of Biotechnology and Pharmaceutical Research > John Tsu-An Hsu > Conference Papers/Meeting Abstract > Item 3990099045/11725

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11725

Title:	Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer
Authors:	Hsu, J;Hung, HC;Yen, WC;Chang, TY;Yen, GJ;Huang, CT;Fnag, MY;Lai, YL;Tsai, YR;Chen, CT;Shih, JC;Hsu, JTA
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Recent studies have revealed that the R-spondins (RSPOs) can mediate with Lgr4 and Lgr5 proteins/Frizzled/LRP receptor complexes as an independent (noncanonical) control of the Wnt pathway. Several lines of evidence supported that RSPOs play a positive role in the regulation of Wnt/beta-catenin signalling. We have identified an anti-RSPO3 antibody (DBPR117; hB1) using a rational design approach. DBPR117 was identified as an ideal candidate to be developed as a therapeutic antibody. DBPR117 was well characterized in a variety of assays including the binding assays, in vitro bioassays, in vivo PDX (patient-derived xenograft), lung cancer or colon cancer CDX (cell line-derived xenograft) models. DBPR117 is capable of binding specifically to the human RSPO3 with novel amino acid sequences in the complementary determining regions (CDRs). DBPR117 showed efficacy in human colon and lung cancers with RSPO3 fusion/overexpression. We are currently evaluating whether antagonizing RSPO3 by DBPR117 would synergize with anti-PD-L1 antibody to combat cancers using syngeneic murine models.
Date:	2018-12
Relation:	Cancer Science. 2018 Dec;109(SI, Suppl. 2):210.
Link to:	https://doi.org/10.1111/cas.13904
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000453773601015
Appears in Collections:	[John Tsu-An Hsu] Conference Papers/Meeting Abstract [Chiung-Tong Chen] Conference Papers/Meeting Abstract [Chuan Shih(2014-2017)] Conference Papers/Meeting Abstract [Wan-Ching Yen] Conference Papers/Meeting Abstract

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