國家衛生研究院 NHRI:Item 3990099045/11725
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    题名: Targeting RSPO3 reduces stem cell function in RSPO3-Fusion-positive colon cancer and RSPO3 high lung cancer
    作者: Hsu, J;Hung, HC;Yen, WC;Chang, TY;Yen, GJ;Huang, CT;Fnag, MY;Lai, YL;Tsai, YR;Chen, CT;Shih, JC;Hsu, JTA
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Recent studies have revealed that the R-spondins (RSPOs) can mediate with Lgr4 and Lgr5 proteins/Frizzled/LRP receptor complexes as an independent (noncanonical) control of the Wnt pathway. Several lines of evidence supported that RSPOs play a positive role in the regulation of Wnt/beta-catenin signalling. We have identified an anti-RSPO3 antibody (DBPR117; hB1) using a rational design approach. DBPR117 was identified as an ideal candidate to be developed as a therapeutic antibody. DBPR117 was well characterized in a variety of assays including the binding assays, in vitro bioassays, in vivo PDX (patient-derived xenograft), lung cancer or colon cancer CDX (cell line-derived xenograft) models. DBPR117 is capable of binding specifically to the human RSPO3 with novel amino acid sequences in the complementary determining regions (CDRs). DBPR117 showed efficacy in human colon and lung cancers with RSPO3 fusion/overexpression. We are currently evaluating whether antagonizing RSPO3 by DBPR117 would synergize with anti-PD-L1 antibody to combat cancers using syngeneic murine models.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(SI, Suppl. 2):210.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773601015
    显示于类别:[徐祖安] 會議論文/會議摘要
    [陳炯東] 會議論文/會議摘要
    [石全(2014-2017)] 會議論文/會議摘要
    [顏婉菁] 會議論文/會議摘要

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