國家衛生研究院 NHRI:Item 3990099045/11726
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 908687      在线人数 : 1063
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11726


    题名: Interferon-stimulated gene 15 promotes lymph node metastasis via interacting Rac1 in oral squamous cell carcinoma cells
    作者: Chen, YL;Wu, WL;Yen, YC;Wang, SH;Shen, YY;Chen, YW
    贡献者: National Institute of Cancer Research;Pathology Core Laboratory
    摘要: Lymph node metastasis is the main factor of poor prognosis in oral squamous cell carcinoma (OSCC) patients. Using proteomic analysis, we found that interferon-stimulated gene 15 (ISG15) was the highest expressed protein related to lymph node metastasis. Abundant ISG15 was also observed in the microarray datasets and immunohistochemical of OSCC patients. In the orthotopic xenograft model, ISG15 knockdown decreased tumor lymphangiogenesis and lymph node metastasis. Similarly, ISG15 knockdown diminished cell migration, invasion and transendothelial migration in OSCC cells. Especially, ISG15-induced cell migration was in an intracellular ISGylation-independent manner and associated with membrane protrusions. Ectopic expression of ISG15 increased Rac1 activity and knockdown of Rac1 impaired ISG15-enhanced migration. Moreover, ISG15 was co-localized and interacted with Rac1 in the region of membrane protrusions by immunofluorescence and proximity ligation asays. Immunoprecipitated ISG15 interacted with Rac1, especially Rac1-GDP form. Our study indicated that ISG15 promotes cell migration and lymph node metastasis via regulation of Rac1 activity and physical interaction with Rac1.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):214.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773601023
    显示于类别:[沈瑩瑩] 會議論文/會議摘要
    [陳雅雯] 會議論文/會議摘要

    文件中的档案:

    档案 大小格式浏览次数
    ISI000453773601023.pdf35KbAdobe PDF297检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈