國家衛生研究院 NHRI:Item 3990099045/11757
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12500/13673 (91%)
造访人次 : 2597610      在线人数 : 400
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11757


    题名: Cardiac output, carotid-femoral pulse wave velocity, and cognitive function impairment in an elderly population
    作者: Chen, C;Chuang, SY;Cheng, HM;Pan, WH
    贡献者: Institute of Population Health Sciences
    摘要: Objective:Low cardiac output has been associated with impaired cognitive function in heart failure patients. We aimed to investigate the relationship between cardiac output and cognitive function in the elderly general population.Design and method:The Cardiovascular Disease Risk Factors two-Township study (CVDFACTS) was a longitudinal cohort study. The on-going sixth wave survey was started in 2015.A total of 331 seniors aged more than 60 years participated in the sixth wave survey and received the Mini-Mental State Examination (MMSE) to evaluate the global cognitive function. Cardiac and arterial function were assessed by measuring cardiac index (CI), ejection fraction, and end-systolic elastance, carotid-femoral pulse wave velocity (cf-PWV), augmentation index (AI) and arterial elastance. The general linear regression and logistic regression were used to evaluate the associations between MMSE and cardiac output and cf-PWV, respectively.Results:Of all cardiovascular parameters, after adjusting for age, gender, and education, only CI (r = 0.16, p-value = 0.0043) and cf-PWV (r = −0.15, p-value = 0.0082) were positively and negatively associated with MMSE, respectively. CI (median: 2.00 L/min/m2) and cf-PWV (median: 13.69 m/sec) were further classified by median into low and high groups. In the multivariable model adjusting for age, sex, education, body mass index, systolic blood pressure, dyslipidemia and diabetes, compared to those elderly with low cf-PWV and high CI (reference group, n = 84), the adjusted difference of MMSE was −0.83 (p-value = 0.033) for low cf-PWV plus low CI (n = 81), was −0.64 (p-value = 0.101) for those with high cf-PWV plus high CI (n = 83), and −0.09 (p-value = 0.021) for high cf-PWV and low CI (n = 83). Moreover, compared to the reference group, the odds ratio (OR) of impaired cognitive function (MMSE score <26) in the above multivariable model was 4.59 (95% confidence interval: 1.12–18.8) for high cf-PWV and low CI, 4.32 (1.11–16.8) for high cf-PWV plus high CI, and 5.97 (1.34–26.7) for low cf-PWV plus low CI.Conclusions:In an elderly population, lower cardiac output was associated with lower MMSE and a higher risk of impaired cognitive function, independent of cf-PWV, a recognized risk factor for dementia in the elderly.
    日期: 2017-09
    關聯: Journal of Hypertension. 2017 Sep;35(Suppl. 2):E350.
    Link to: http://dx.doi.org/10.1097/01.hjh.0000524038.48627.13
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0263-6352&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000456877503197
    显示于类别:[莊紹源] 會議論文/會議摘要

    文件中的档案:

    档案 大小格式浏览次数
    ISI000456877503197.pdf53KbAdobe PDF315检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈