國家衛生研究院 NHRI:Item 3990099045/11757
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 856898      線上人數 : 954
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11757


    題名: Cardiac output, carotid-femoral pulse wave velocity, and cognitive function impairment in an elderly population
    作者: Chen, C;Chuang, SY;Cheng, HM;Pan, WH
    貢獻者: Institute of Population Health Sciences
    摘要: Objective:Low cardiac output has been associated with impaired cognitive function in heart failure patients. We aimed to investigate the relationship between cardiac output and cognitive function in the elderly general population.Design and method:The Cardiovascular Disease Risk Factors two-Township study (CVDFACTS) was a longitudinal cohort study. The on-going sixth wave survey was started in 2015.A total of 331 seniors aged more than 60 years participated in the sixth wave survey and received the Mini-Mental State Examination (MMSE) to evaluate the global cognitive function. Cardiac and arterial function were assessed by measuring cardiac index (CI), ejection fraction, and end-systolic elastance, carotid-femoral pulse wave velocity (cf-PWV), augmentation index (AI) and arterial elastance. The general linear regression and logistic regression were used to evaluate the associations between MMSE and cardiac output and cf-PWV, respectively.Results:Of all cardiovascular parameters, after adjusting for age, gender, and education, only CI (r = 0.16, p-value = 0.0043) and cf-PWV (r = −0.15, p-value = 0.0082) were positively and negatively associated with MMSE, respectively. CI (median: 2.00 L/min/m2) and cf-PWV (median: 13.69 m/sec) were further classified by median into low and high groups. In the multivariable model adjusting for age, sex, education, body mass index, systolic blood pressure, dyslipidemia and diabetes, compared to those elderly with low cf-PWV and high CI (reference group, n = 84), the adjusted difference of MMSE was −0.83 (p-value = 0.033) for low cf-PWV plus low CI (n = 81), was −0.64 (p-value = 0.101) for those with high cf-PWV plus high CI (n = 83), and −0.09 (p-value = 0.021) for high cf-PWV and low CI (n = 83). Moreover, compared to the reference group, the odds ratio (OR) of impaired cognitive function (MMSE score <26) in the above multivariable model was 4.59 (95% confidence interval: 1.12–18.8) for high cf-PWV and low CI, 4.32 (1.11–16.8) for high cf-PWV plus high CI, and 5.97 (1.34–26.7) for low cf-PWV plus low CI.Conclusions:In an elderly population, lower cardiac output was associated with lower MMSE and a higher risk of impaired cognitive function, independent of cf-PWV, a recognized risk factor for dementia in the elderly.
    日期: 2017-09
    關聯: Journal of Hypertension. 2017 Sep;35(Suppl. 2):E350.
    Link to: http://dx.doi.org/10.1097/01.hjh.0000524038.48627.13
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0263-6352&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000456877503197
    顯示於類別:[莊紹源] 會議論文/會議摘要

    文件中的檔案:

    檔案 大小格式瀏覽次數
    ISI000456877503197.pdf53KbAdobe PDF291檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋