國家衛生研究院 NHRI:Item 3990099045/1220

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Title:	Impaired phagocytosis of capsular serotypes K1 or K2 Klebsiella pneumoniae in type 2 diabetes mellitus patients with poor glycemic control
Authors:	Lin, JC;Siu, LK;Fung, CP;Tsou, HH;Wang, JJ;Chen, CT;Wang, SC;Chang, FY
Contributors:	Division of Biotechnology and Pharmaceutical Research;Division of Clinical Research;Division of Biostatistics and Bioinformatics
Abstract:	Context: Diabetes mellitus (DM) and capsular serotypes K1 and K2 Klebsiella pneumoniae have been identified as risk factors for liver abscess and complicated endophthalmitis. Objective: The objective of this study was to determine whether poor glycemic control contributes to the development of capsular serotype K1 or K2 K. pneumoniae liver abscess. Design and Setting: Neutrophil phagocytosis in patients with type 2 DM and nondiabetic controls was compared with isolates from liver abscess. Phagocytic rates of 18 K1/K2 and nine non-K1/K2 K. pneumoniae strains were evaluated by flow cytometry and electron microscopy. Patients or Study Participants: Forty patients with type 2 diabetes, 14 with good glycemic control, 26 with poor glycemic control, and 13 age-matched healthy normal subjects, were studied. Main Outcome Measures: Phagocytic rate of K. pneumoniae was measured. Results: Phagocytosis of serotype K1/K2 isolates by neutrophils from diabetics was significantly less than normal controls ( P < 0.01). Further analysis revealed that, in type 2 DM patients with poor glycemic control, phagocytosis of K1/K2 was remarkably impaired at 10 min (25.2 +/- 1.7 vs. 42.4 +/- 1.8%) and persisted until 60 min ( 51 +/- 1.2 vs. 59.4 +/- 1.4%; P < 0.01), but in type 2 DM patients with good glycemic control were similar at 10 min ( 38.2 +/- 1.7% vs. 42.4 +/- 1.8%) and at 60 min (57 +/- 0.3% vs. 59.4 +/- 1.4%; P = 0.2). No significant difference in the phagocytosis of non-K1/K2 K. pneumoniae among all subjects was observed. Conclusions: Poor glycemic control plays a role in impairing neutrophil phagocytosis of K1/K2 K. pneumoniae, but does not significantly affect the phagocytosis of non-K1/K2 K. pneumoniae. This study identifies poor glycemic control as a risk factor for susceptibility to serotype K1/K2 K. pneumoniae liver abscess and complicated endophthalmitis.
Keywords:	Endocrinology & Metabolism
Date:	2006-08
Relation:	Journal of Clinical Endocrinology and Metabolism. 2006 Aug;91(8):3084-3087.
Link to:	http://dx.doi.org/10.1210/jc.2005-2749
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-972X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000239603700044
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33747639229
Appears in Collections:	[Chiung-Tong Chen] Periodical Articles [Leung-Kei Siu] Periodical Articles [Hsiao-Hui Sophie Tsou] Periodical Articles

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