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生技與藥物研究所
陳炯東
--期刊論文
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Natural fucoidans inhibit coronavir...
Integrating ultrabright polymer dot...
Advancing precision therapy for col...
DBPR116, a prodrug of BPRMU191, in ...
Discovery of a mu-opioid receptor m...
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Natural fucoidans inhibit coronavir...
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顯示項目1-25 / 160. (共7頁)
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2025-02
Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin[Erratum:Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688.]
Biochemical Pharmacology. 2025 Feb;232:Article number 116753.
2025-01-05
Integrating ultrabright polymer dots and stereo NIR-II imager for assessing anti-angiogenic drugs in oral cancer model
Journal of Cellular and Molecular Medicine. 2025 Jan 05;29(1):Article number e70324.
2025-01
Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models
Pharmacological Research. 2025 Jan;211:Article number 107556.
2024-11-21
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia
Cell Chemical Biology. 2024 Nov 21;31(11):1885-1898.e10.
2024-11
DBPR116, a prodrug of BPRMU191, in combination with naltrexone as a safer opioid analgesic than morphine via peripheral administration
Journal of Medicinal Chemistry. 2024 Nov 14;67(21):19777-19790.
2024-06-01
Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus
Molecular Cancer Therapeutics. 2024 Jun 01;23(6):766-779.
2024-02-16
Postfermented tea extract potently alleviates glucose metabolism disorders in vitro and in vivo
ACS Food Science and Technology. 2024 Feb 16;4(2):479-490.
2023-07-20
Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin
Biochemical Pharmacology. 2023 Jul 20;215:Article number 115688.
2023-02-07
Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer
Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
2023-01-19
The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b [Erratum:Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.]
Pharmaceutics. 2023 Jan 19;15(2):Article number 342.
2022-12-05
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation
European Journal of Medicinal Chemistry. 2022 Dec 5;243:Article number 114728.
2022-12-02
Omicron-specific mRNA vaccine induced cross-protective immunity against ancestral SARS-CoV-2 infection with low neutralizing antibodies
Journal of Medical Virology. 2022 Dec 2;95:Article number e28370.
2022-11-15
BPR0C261, an analogous of microtubule disrupting agent D-24851 enhances the radiosensitivity of human non-small cell lung cancer cells via p53-dependent and p53-independent pathways
International Journal of Molecular Sciences. 2022 Nov 15;23(22):Article number 14083.
2022-11-01
Peritoneal effluent MicroRNA profile for detection of encapsulating peritoneal sclerosis
Clinica Chimica Acta. 2022 Nov 1;536:45-55.
2022-11
Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone
Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
2022-10-13
Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate
Journal of Medicinal Chemistry. 2022 Oct 13;65(19):12802-12824.
2022-10-03
Protective effect of CXCR4 antagonist DBPR807 against ischemia-reperfusion injury in a rat and porcine model of myocardial infarction: Potential adjunctive therapy for percutaneous coronary intervention
International Journal of Molecular Sciences. 2022 Oct 3;23(19):Article number 11730.
2022-07-21
The synergistic inhibition of coronavirus replication and induced cytokine production by ciclesonide and the tylophorine-based compound dbq33b
Pharmaceutics. 2022 Jul 21;14(7):Article number 1511.
2022-06-21
Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids
Pharmaceutics. 2022 Jun 21;14(7):Article number 1316.
2022-05-02
Furin and TMPRSS2 resistant spike induces robust humoral and cellular immunity against SARS-CoV-2 lethal infection
Frontiers in Immunology. 2022 May 2;13:Article number 872047.
2022-03-02
Discovery of potential neuroprotective agents against paclitaxel-induced peripheral neuropathy
Journal of Medicinal Chemistry. 2022 Mar 2;65(6):4767-4782.
2022-02-15
Click chemistry and multicomponent reaction for linker diversification of zinc dipicolylamine-based drug conjugates
Frontiers in Chemistry. 2022 Feb 15;9:Article number 822587.
2021-12
Implanted islet mass influences the effects of dipeptidyl peptidase-IV inhibitor LAF237 on transplantation outcomes in diabetic mice
Biomedical Journal. 2021 Dec;44(6 Suppl 2):S210-S217.
2021-11-15
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization
European Journal of Medicinal Chemistry. 2021 Nov 15;224:Article number 113673.
2021-10-14
Discovery of BPR1R024, an orally active and selective CSF1R inhibitor that exhibits antitumor and immunomodulatory activity in a murine colon tumor model
Journal of Medicinal Chemistry. 2021 Oct 14;64(19):14477-14497.
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