國家衛生研究院 NHRI:Item 3990099045/12250
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    题名: Investigation the main effects of genetic variants and polygenic risk score of personality on suicidal behavior
    作者: Su, MH;Chen, HC;Liu, YL;Tsai, SJ;Chen, IM;Lu, ML;Chiu, YH;Chen, CH;Huang, MC;Lin, SK;Lu, RB;Liao, SC;Kuo, PH
    贡献者: Center for Neuropsychiatric Research
    摘要: Background: Suicide is the second leading cause of death but yet lack of reliable predictors for suicide attempt (SA). Mood disorders are known risk factor for suicide. In addition, personality traits affect human behaviors and decision making through diverse biological functioning and might moderate the risk of suicidal behaviors. The aims of this study is to examine whether individuals carry more genetic variants related to specific personality traits increase the risk for SA. We also calculated genetic correlations between personality traits and SA. Methods: We included mood disorder patients and community controls in the present study. All patients met diagnostic criteria of major depressive disorder (MDD) or bipolar disorder (BPD) using the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. The community controls were obtained from Taiwan Biobank Dataset. There were 735 BPD, 614 MDD, and 13,253 control subjects retained in the analysis. Information of SA was collected in mood disorder patients. The polygenic risk score (PRS) was calculated for two personality traits: Extraversion (E) (n = 63,030) and Neuroticism (N) (n = 63,661) based on Genetics of Personality Consortium phase 2 (GPC-2) dataset. We evaluated the risk of SA in quintile of each personality PRS. The risk of SA was estimated in case-only design in mood disorder patients, as well as in all subjects to include controls and patients. In addition, we calculated genetic correlation between personality trait N/E and SA using LD regression method. Results: No significant associations between PRS of personality traits and SA were found. However, there was an increasing trend of SA risk for the highest PRS quintile of neuroticism (OR = 1.633, CI = 1.001-2.663) compared to the lowest neuroticism quintile in BPD patients. There was no significant genetic correlation between either E or N and SA in case-only model. Analyses for all samples are ongoing. Discussion: There is weak association between N-related genetic variants and the risk of SA. However, the genetic correlation between them was not significant. There have potential other factors involved in the possible pathways for suicide.
    日期: 2019-10
    關聯: European Neuropsychopharmacology. 2019 Oct;29:S146-S147.
    Link to: http://dx.doi.org/10.1016/j.euroneuro.2019.08.064
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-977X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000488216600268
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