國家衛生研究院 NHRI:Item 3990099045/12250
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 858829      線上人數 : 810
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12250


    題名: Investigation the main effects of genetic variants and polygenic risk score of personality on suicidal behavior
    作者: Su, MH;Chen, HC;Liu, YL;Tsai, SJ;Chen, IM;Lu, ML;Chiu, YH;Chen, CH;Huang, MC;Lin, SK;Lu, RB;Liao, SC;Kuo, PH
    貢獻者: Center for Neuropsychiatric Research
    摘要: Background: Suicide is the second leading cause of death but yet lack of reliable predictors for suicide attempt (SA). Mood disorders are known risk factor for suicide. In addition, personality traits affect human behaviors and decision making through diverse biological functioning and might moderate the risk of suicidal behaviors. The aims of this study is to examine whether individuals carry more genetic variants related to specific personality traits increase the risk for SA. We also calculated genetic correlations between personality traits and SA. Methods: We included mood disorder patients and community controls in the present study. All patients met diagnostic criteria of major depressive disorder (MDD) or bipolar disorder (BPD) using the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. The community controls were obtained from Taiwan Biobank Dataset. There were 735 BPD, 614 MDD, and 13,253 control subjects retained in the analysis. Information of SA was collected in mood disorder patients. The polygenic risk score (PRS) was calculated for two personality traits: Extraversion (E) (n = 63,030) and Neuroticism (N) (n = 63,661) based on Genetics of Personality Consortium phase 2 (GPC-2) dataset. We evaluated the risk of SA in quintile of each personality PRS. The risk of SA was estimated in case-only design in mood disorder patients, as well as in all subjects to include controls and patients. In addition, we calculated genetic correlation between personality trait N/E and SA using LD regression method. Results: No significant associations between PRS of personality traits and SA were found. However, there was an increasing trend of SA risk for the highest PRS quintile of neuroticism (OR = 1.633, CI = 1.001-2.663) compared to the lowest neuroticism quintile in BPD patients. There was no significant genetic correlation between either E or N and SA in case-only model. Analyses for all samples are ongoing. Discussion: There is weak association between N-related genetic variants and the risk of SA. However, the genetic correlation between them was not significant. There have potential other factors involved in the possible pathways for suicide.
    日期: 2019-10
    關聯: European Neuropsychopharmacology. 2019 Oct;29:S146-S147.
    Link to: http://dx.doi.org/10.1016/j.euroneuro.2019.08.064
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-977X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000488216600268
    顯示於類別:[劉玉麗] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000488216600268.pdf77KbAdobe PDF251檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋