國家衛生研究院 NHRI:Item 3990099045/1251
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/1251


    题名: Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents
    作者: Liou, JP;Chang, CW;Song, JS;Yang, YN;Yeh, CF;Tseng, HY;Lo, YK;Chang, YL;Chang, CM;Hsieh, HP
    贡献者: Division of Biotechnology and Pharmaceutical Research;Division of Molecular and Genomic Medicine
    摘要: A new type of inhibitor of tubulin polymerization was discovered on the basis of the combretastatin molecular skeleton. The lead compounds in this series, compounds 6 and 7, strongly inhibited tubulin polymerization in vitro and significantly arrested cells at the G(2)/M phase. Compounds 6 and 7 yielded 50- to 100-fold lower IC50 values than did combretastatin A-4 against Colo 205, NUGC3, and HA22T human cancer cell lines as well as similar or greater growth inhibitory activities than did combretastain A-4 against DLD-1, HR, MCF-7, DU145, HONE-1, and MES-SA/DX5 human cancer cell lines. Structure-activity relationship information revealed that introduction of an amino group at the ortho position of the benzophenone ring plays an integral role for increased growth inhibition.
    关键词: Chemistry, Medicinal
    日期: 2002-06-06
    關聯: Journal of Medicinal Chemistry. 2002 Jun;45(12):2556-2562.
    Link to: http://pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/2002/45/i12/abs/jm010365+.html
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000175957700023
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037030604
    显示于类别:[謝興邦] 期刊論文
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