國家衛生研究院 NHRI:Item 3990099045/12582

NHRI > National Institute of Environmental Health Sciences > Louis W. Chang(1999-2009) > Books/Book Section > Item 3990099045/12582

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Title:	Fetal minamata disease: A human episode of congenital methylmercury poisoning
Authors:	Dos Santos, AA;Chang, LW;Guo, GL;Aschner, M
Contributors:	National Institute of Environmental Health Sciences
Abstract:	This chapter addresses well-known episodes of methylmercury (MeHg) poisoning, highlighting differences between the epidemics in Minamata Bay, Japan, and Iraq. Special attention is directed to the cognitive effects of MeHg in neonates and children, and the underlying changes in cytoarchitecture. Finally, we discuss the biomolecular basis of neurotoxicity in fetal Minamata disease emphasizing neural cell adhesion molecule and changes in neuronal cytoskeletal proteins. Cell polarization and migration patterns require dynamic rearrangement of the actin and microtubule cytoskeletons via intracellular signaling pathways involving Rho family GTPases. The Rho-associated protein kinases are central regulators of the actin cytoskeleton downstream of the small GTPase Rho and their role is discussed within the context of MeHg-induced injury.
Date:	2018-01-30
Relation:	Handbook of Developmental Neurotoxicology. 2018 Jan 30:399-406.
Link to:	http://dx.doi.org/10.1016/B978-0-12-809405-1.00035-3
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85070721864
Appears in Collections:	[Louis W. Chang(1999-2009)] Books/Book Section

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