國家衛生研究院 NHRI:Item 3990099045/12582
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12500/13673 (91%)
造訪人次 : 2478963      線上人數 : 76
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12582


    題名: Fetal minamata disease: A human episode of congenital methylmercury poisoning
    作者: Dos Santos, AA;Chang, LW;Guo, GL;Aschner, M
    貢獻者: National Institute of Environmental Health Sciences
    摘要: This chapter addresses well-known episodes of methylmercury (MeHg) poisoning, highlighting differences between the epidemics in Minamata Bay, Japan, and Iraq. Special attention is directed to the cognitive effects of MeHg in neonates and children, and the underlying changes in cytoarchitecture. Finally, we discuss the biomolecular basis of neurotoxicity in fetal Minamata disease emphasizing neural cell adhesion molecule and changes in neuronal cytoskeletal proteins. Cell polarization and migration patterns require dynamic rearrangement of the actin and microtubule cytoskeletons via intracellular signaling pathways involving Rho family GTPases. The Rho-associated protein kinases are central regulators of the actin cytoskeleton downstream of the small GTPase Rho and their role is discussed within the context of MeHg-induced injury.
    日期: 2018-01-30
    關聯: Handbook of Developmental Neurotoxicology. 2018 Jan 30:399-406.
    Link to: http://dx.doi.org/10.1016/B978-0-12-809405-1.00035-3
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85070721864
    顯示於類別:[張惠華(1999-2009)] 圖書

    文件中的檔案:

    沒有與此文件相關的檔案.



    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋