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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1264


    Title: Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold
    Authors: Coumar, MS;Wu, JS;Leou, JS;Tan, UK;Chang, CY;Chang, TY;Lin, WH;Hsu, JTA;Chao, YS;Wu, SY;Hsieh, HP
    Contributors: Division of Biotechnology and Pharmaceutical Research
    Abstract: Tricyclic 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione was identified as a novel scaffold for Aurora kinase A inhibition through virtual screening. SAR exploration coupled with molecular modeling of 8a reveals the minimum pharmacophore requirements for Aurora kinase A inhibition. (c) 2008 Elsevier Ltd. All rights reserved.
    Keywords: Chemistry, Medicinal;Chemistry, Organic
    Date: 2008-03-01
    Relation: Bioorganic and Medicinal Chemistry Letters. 2008 Mar;18(5):1623-1627.
    Link to: http://dx.doi.org/10.1016/j.bmcl.2008.01.068
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000254180200016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=40149097462
    Appears in Collections:[謝興邦] 期刊論文
    [伍素瑩] 期刊論文
    [徐祖安] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

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