國家衛生研究院 NHRI:Item 3990099045/12934

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Title:	Snake venomics of individual specimens of protobothrops mucrosquaniatus reveal systematic geographic variation and molecular characterization
Authors:	Chiang, LC;Sung, WC;Wu, WG
Contributors:	National Institute of Infectious Diseases and Vaccinology
Abstract:	Protobothrops mucrosquamatus, also known as the habu, is a major venomous species causing viper snake evenomings in Pan-Asia. A study in Taiwan recorded 250 habu envenomings annually, which accounts for approximately 23% of total snakebites. Habu contains a high abundance of necrotic and hemorrhagic toxins that can induce local inﬂammation, hemorrhage, necrosis and edema in snakebite victims. Administration of antivenom has been recommended for therapeutic treatment; however, the therapeutic effect might vary with venom composition. A further proteomic analysis on individual habu snake venom is required to identify the toxin variants which might affect the neutralization efﬁcacy of antivenom. In the study, venom was collected from a total of 34 individual habu snakes from various regions in Taiwan, and venomic results revealed that there is a wide dynamic range in the composed snake venom metalloproteinases (SVMPs) and phospholipases A2 (PLA2s). In addition, there are four PLA2 variants identiﬁed from these geographic samples, which can be markers to identify the putative subspecies of habu from various regions in Taiwan. We conclude that venomic analyses of intra-speciﬁc variation of proteomic proﬁles of snake venoms can provide useful information for better snakebite management.
Date:	2019-02
Relation:	Toxicon. 2019 Feb;158(Suppl. 1):S50.
Link to:	http://dx.doi.org/10.1016/j.toxicon.2018.10.175
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0041-0101&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000565208400168
Appears in Collections:	[Wang-Chou Sung] Conference Papers/Meeting Abstract

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