國家衛生研究院 NHRI:Item 3990099045/12934
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 915389      線上人數 : 1307
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12934


    題名: Snake venomics of individual specimens of protobothrops mucrosquaniatus reveal systematic geographic variation and molecular characterization
    作者: Chiang, LC;Sung, WC;Wu, WG
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: Protobothrops mucrosquamatus, also known as the habu, is a major venomous species causing viper snake evenomings in Pan-Asia. A study in Taiwan recorded 250 habu envenomings annually, which accounts for approximately 23% of total snakebites. Habu contains a high abundance of necrotic and hemorrhagic toxins that can induce local inflammation, hemorrhage, necrosis and edema in snakebite victims. Administration of antivenom has been recommended for therapeutic treatment; however, the therapeutic effect might vary with venom composition. A further proteomic analysis on individual habu snake venom is required to identify the toxin variants which might affect the neutralization efficacy of antivenom. In the study, venom was collected from a total of 34 individual habu snakes from various regions in Taiwan, and venomic results revealed that there is a wide dynamic range in the composed snake venom metalloproteinases (SVMPs) and phospholipases A2 (PLA2s). In addition, there are four PLA2 variants identified from these geographic samples, which can be markers to identify the putative subspecies of habu from various regions in Taiwan. We conclude that venomic analyses of intra-specific variation of proteomic profiles of snake venoms can provide useful information for better snakebite management.
    日期: 2019-02
    關聯: Toxicon. 2019 Feb;158(Suppl. 1):S50.
    Link to: http://dx.doi.org/10.1016/j.toxicon.2018.10.175
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0041-0101&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000565208400168
    顯示於類別:[宋旺洲] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000565208400168.pdf50KbAdobe PDF216檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋