國家衛生研究院 NHRI:Item 3990099045/13109
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    题名: Tumor-agnostic inhibitors in oncology: A new phase for precision medicine
    作者: Li, MC;Hsieh, HP
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: The study of precision medicine is flourishing in recent decades. Tumor-agnostic therapy is one of the targeted therapies, which can treat the malignant cells regardless of where they grow. Herein we reviewed currently the U.S. FDA-approved tumor-agnostic therapies: one monoclonal antibody as a PD-1 inhibitor called pembrolizumab and four small-molecule kinase inhibitors, larotrectinib, entrectinib, selpercatinib, and pralsetinib. We also summarized the reported synthetic routes toward three drugs and some developing candidates under clinical trials as tumor-agnostic therapy.
    日期: 2020-12-10
    關聯: Journal of the Chinese Chemical Society. 2020 Dec 10;67(12):2216-2224.
    Link to: http://dx.doi.org/10.1002/jccs.202000377
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-4536&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000597230800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85097413956
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