國家衛生研究院 NHRI:Item 3990099045/13129
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13129


    Title: Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia
    Authors: Blechter, B;Wong, JYY;Agnes Hsiung, C;Hosgood, HD;Yin, Z;Shu, XO;Zhang, H;Shi, J;Song, L;Song, M;Zheng, W;Wang, Z;Caporaso, N;Burdette, L;Yeager, M;Berndt, SI;Teresa Landi, M;Chen, CJ;Chang, GC;Hsiao, CF;Tsai, YH;Chen, KY;Huang, MS;Su, WC;Chen, YM;Chien, LH;Chen, CH;Yang, TY;Wang, CL;Hung, JY;Lin, CC;Perng, RP;Chen, CY;Chen, KC;Li, YJ;Yu, CJ;Chen, YS;Chen, YH;Tsai, FY;Jie Seow, W;Bassig, BA;Hu, W;Ji, BT;Wu, W;Guan, P;He, Q;Gao, YT;Cai, Q;Chow, WH;Xiang, YB;Lin, D;Wu, C;Wu, YL;Shin, MH;Hong, YC;Matsuo, K;Chen, K;Pik Wong, M;Lu, D;Jin, L;Wang, JC;Seow, A;Wu, T;Shen, H;Fraumeni, JF;Yang, PC;Chang, IS;Zhou, B;Chanock, SJ;Rothman, N;Chatterjee, N;Lan, Q
    Contributors: Institute of Population Health Sciences;National Institute of Cancer Research
    Abstract: We previously identified 10 lung adenocarcinoma susceptibility loci in a genome-wide association study (GWAS) conducted in the Female Lung Cancer Consortium in Asia (FLCCA), the largest genomic study of lung cancer among never-smoking women to date. Furthermore, household coal use for cooking and heating has been linked to lung cancer in Asia, especially in Xuanwei, China. We investigated the potential interaction between genetic susceptibility and coal use in FLCCA. We analyzed GWAS-data from Taiwan, Shanghai, and Shenyang (1472 cases; 1497 controls), as well as a separate study conducted in Xuanwei (152 cases; 522 controls) for additional analyses. We summarized genetic susceptibility using a polygenic risk score (PRS), which was the weighted sum of the risk-alleles from the 10 previously identified loci. We estimated associations between a PRS, coal use (ever/never), and lung adenocarcinoma with multivariable logistic regression models, and evaluated potential gene-environment interactions using likelihood ratio tests. There was a strong association between continuous PRS and lung adenocarcinoma among never coal users (Odds Ratio (OR) = 1.69 (95% Confidence Interval (CI) = 1.53, 1.87), p=1 × 10(-)(26)). This effect was attenuated among ever coal users (OR = 1.24 (95% CI: 1.03, 1.50), p = 0.02, p-interaction = 6 × 10(-3)). We observed similar attenuation among coal users from Xuanwei. Our study provides evidence that genetic susceptibility to lung adenocarcinoma among never-smoking Asian women is weaker among coal users. These results suggest that lung cancer pathogenesis may differ, at least partially, depending on exposure to coal combustion products. Notably, these novel findings are among the few instances of sub-multiplicative gene-environment interactions in the cancer literature.
    Date: 2020-12-29
    Relation: Environment International. 2020 Dec 29;147:Article number 105975.
    Link to: http://dx.doi.org/10.1016/j.envint.2020.105975
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0160-4120&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000614535400002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85098869659
    Appears in Collections:[Chao A. Hsiung] Periodical Articles
    [I-Shou Chang] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles

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